Visual Analysis of Long Lasting Insecticidal Nets to Maximise Universal Access (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/visual-analysis-of-long-lasting-insecticidal-nets-to-maximise-universal-access
vital in reducing the malaria burden among children over the last 20 years. Reductions have stagnated and resources available for control are half what is needed to meet malaria control milestones. Standard [...] between products, influencing their value-for-money. This project will deliver information to National Malaria Control Programs (NMCP) that enables them to 1) select durable and cost-effective LLINs to buy, 2) [...] NMCP=medium to select the best LLINs for their setting to optimize the...
Dietary diversity in primary schoolchildren of south-central Côte d'Ivoire and risk factors for non-communicable diseases (Publications)
prediabetes and malaria infection, as well as medium and high DDS. Overweight was associated with malaria infection and moderate anaemia. CONCLUSION: Overweight, prediabetes, low HDL-C, malaria, and anaemia [...] the primary caretaker according to the guideline of Food and Agriculture Organization. Anaemia, malaria, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and blood [...] health in Taabo. Our findings highlight interactions between infectious...
WHO TVC (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/who-tvc
Increasing coverage of malaria vector control interventions globally has led to significant reductions in disease burden. However due to its high recurrent cost, there is a need to determine if and when [...] reduced. We conduct literature reviews and simulate a mathematical model of Plasmodium falciparum malaria epidemiology to determine the impact of scaling back vector control on transmission and disease.
Discovery and structure-activity relationships of quinazolinone-2-carboxamide derivatives as novel orally efficacious antimalarials (Publications)
against laboratory-resistant strains of malaria. Profiling of 19f suggested a fast in vitro killing profile. In vivo activity in a murine model of human malaria in a dose-dependent manner constitutes a
Artemisinins and synthetic trioxolanes in the treatment of helminth infections (Publications)
following recommended malaria treatment schedules, found an effect against schistosomiasis. SUMMARY: Artemisinin-based combination therapies are increasingly deployed against malaria, and hence there is [...] that artemisinin-based combination therapy might have on trematode infections in settings where malaria and helminthiases are co-endemic. RECENT FINDINGS: The artemisinins and synthetic trioxolanes possess
Antimalarial agents derived from metal-amodiaquine complexes with activity in multiple stages of the <em>Plasmodium</em> life cycle (Publications)
Malaria is the one of the deadliest infectious diseases worldwide. Chemically, quinolines are excellent ligands for metal coordination and are deployed as drugs for malaria treatment. There is a growing [...] coordination with antimalarial quinolines is a potential chemical tool for drug design and discovery in malaria and other infectious diseases susceptible to quinoline treatment.
Pan-Africa Network for Genomic Surveillance of Poverty Related Diseases and Emerging Pathogens (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/pan-africa-network-for-genomic-surveillance-of-poverty-related-diseases-and-emerging-pathogens
The main objective of the PANGenS project is to use genomic epidemiology of tuberculosis, malaria and emerging and re-emerging pathogens in Africa to better understand disease etiology, dynamics of disease [...] will aid infectious disease monitoring, and genomic surveillance will detect drug-resistant TB and malaria parasites. To achieve this, PANGenS will develop genomic epidemiology capacity across Africa by [...] components, from wet lab to bioinformatics, and to establish proof-of-concept...
The impact of using primaquine without prior G6PD testing: a case series describing the obstacles to the medical management of haemolysis (Publications)
vivax malaria in glucose-6-phosphate dehydrogenase (G6PD) deficient individuals employs weekly primaquine dosing. This is the only recommended regimen for this patient sub-group. If national malaria programs [...] with unknown G6PD status from two different countries were prescribed primaquine as per national malaria program guidelines. During treatment both patients presented to the clinic with symptoms of anaemia
Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across... (Publications)
blood life-cycle stage of the human malaria parasite Plasmodium falciparum. Several compounds displayed high in vivo efficacy in two different mouse models for malaria, P. berghei-infected mice and P. f
Drug Discovery Work (Page)
https://www.swisstph.ch/en/about/mpi/parasite-chemotherapy/drug-discovery-work
evaluation of new compounds. The Medicines for Malaria Venture (MMV) Foundation supports the project ‘Syntheticperoxides’ and the new projects ‘Oral diamidines for malaria’. With a master contract with the MMV [...] Drug Discovery Work Tropical parasitic diseases, as malaria, African sleeping sickness, Chagas disease or Leishmaniasis represent still a large health risk for a majority of the worlds population. These [...] trematodes. Links WHO/TDR European COST B22 Drugs for Neglected Diseases...