Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and... (Publications)
To ascertain the structure-activity relationship of the core 1,2,4-trioxolane substructure of dispiro ozonides OZ277 and OZ439, we compared the antimalarial activities and ADME profiles of the 1,2-dio
Optimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal... (Publications)
The cysteine protease rhodesain of Trypanosoma brucei parasites causing African sleeping sickness has emerged as a target for the development of new drug candidates. Based on a triazine nitrile moiety
Insulin-like growth factor-1 promoter polymorphisms and colorectal cancer: a functional genomics approach (Publications)
RATIONALE: Insulin-like growth factor-1 (IGF1) has been proposed to mediate the obesity-related carcinogenic effects of "Western lifestyle". While genetic factors explain at least half of inter-indivi
Occurrence of <em>Giardia lamblia</em> in recreational streams in Basel-Landschaft, Switzerland (Publications)
Little is known about the environmental occurrence of the pathogenic organism Giardia lamblia in Switzerland. To provide a better insight into the importance of G. lamblia, a cheap, effective and easy
In vitro and in vivo activities of synthetic trioxolanes against major human schistosome species (Publications)
Schistosomiasis is a parasitic disease that remains of considerable public health significance in tropical and subtropical environments. Since the mainstay of schistosomiasis control is chemotherapy w
