The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone (Publications)
An unsaturated dispiro 1,2,4,5-tetraoxane formed by peroxidation of (+)-dihydrocarvone was converted into four structurally diverse derivatives. X-ray crystallographic analysis shows that the structur
Effectiveness of dog rabies vaccination programmes: comparison of owner-charged and free vaccination campaigns (Publications)
We investigated the percentage of dogs that could be vaccinated against rabies by conducting a pilot campaign in N'Djamena, Chad. Owners were charged US$4.13 per dog vaccinated, and 24% of all dogs in
Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers) (Publications)
Six tetraoxanes had 50% inhibitory concentrations in the range of 10 to 100 ng/ml against Plasmodium falciparum, whereas the corresponding hexaoxonanes had minimal antimalarial activity. The lack of i
Development and validation of a clinical decision rule for the diagnosis of influenza (Publications)
INTRODUCTION: A clinical decision rule to improve the accuracy of a diagnosis of influenza could help clinicians avoid unnecessary use of diagnostic tests and treatments. Our objective was to develop
Prenatal exposure to a farm environment modifies atopic sensitization at birth (Publications)
BACKGROUND: Previous cross-sectional surveys have suggested that maternal exposure to animal sheds during pregnancy exerted a protective effect on atopic sensitization in children lasting until school
Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from <em>Scleria striatinux</em> with antiplasmodial activity (Publications)
Okundoperoxide (1) was isolated by bioassay-guided fractionation of extracts from Scleria striatinux (syn. S. striatonux). The compound contains a cyclic endoperoxide structural moiety and possesses m