Costing RTS,S introduction in Burkina Faso, Ghana, Kenya, Senegal, Tanzania, and Uganda: a generalizable approach drawing on publicly available data (Publications)
Recent results from the phase 3 trial of RTS,S/AS01 malaria vaccine show that the vaccine induced partial protection against clinical malaria in infants and children; given the high burden of the disease [...] disease it is currently considered for use in malaria endemic countries. To inform adoption decisions the paper proposes a generalizable methodology to estimate the cost of vaccine introduction using routinely
Effect of large-scale social marketing of insecticide-treated nets on child survival in rural Tanzania (Publications)
BACKGROUND: Insecticide-treated nets have proven efficacy as a malaria-control tool in Africa. However, the transition from efficacy to effectiveness cannot be taken for granted. We assessed coverage and [...] programme for insecticide-treated nets in two rural districts of southern Tanzania with high perennial malaria transmission. METHODS: Socially marketed insecticide-treated nets were introduced step-wise over [...] INTERPRETATION: Social marketing of insecticide-treated nets has great...
Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, and praziquantel against <em>Schistosoma haematobium</em>: randomized,... (Publications)
Schistosoma who were treated with a mefloquine-artesunate combination against malaria might have a dual benefit: clearance of malaria parasitemia and reduction of schistosomiasis-related morbidity. CLINICAL [...] and praziquantel (40 mg/kg) against Schistosoma haematobium. The effects on Schistosoma mansoni, malaria parasitemia, soil-transmitted helminths, and intestinal protozoa were also determined. RESULTS: A
The influence of zinc supplementation on morbidity due to <em>Plasmodium falciparum</em>: a randomized trial in preschool children in Papua New Guinea (Publications)
determine the influence of zinc on malaria morbidity we conducted a randomized placebo-controlled trial of daily zinc supplementation in children residing in a malaria endemic region of Papua New Guinea [...] mg elemental zinc (n = 136) or placebo (n = 138) for 6 days a week for 46 weeks. Slide-confirmed malaria episodes were detected by surveillance of cases self-reporting to a local health center. Cross-sectional
Asymptomatic <em>Plasmodium</em> infection and glycemic control in adults: results from a population-based survey in south-central Côte d'Ivoire (Publications)
associations of Plasmodium infection (PI) with fasting glucose (FG) and glycated hemoglobin (HbA1c) in malaria-endemic south-central Cote d'Ivoire. METHODS: We studied 979 participants (non-pregnant; no treated [...] Fasting venous blood was obtained for PI, FG, and HbA1c assessment. We defined PI as a positive malaria rapid diagnostic test (RDT) or microscopic identification of Plasmodium species. We applied multivariable [...] diagnosis in the presence of asymptomatic PI may misclassify or...
Mosquito net use in early childhood and survival to adulthood in Tanzania (Publications)
BACKGROUND It has been hypothesized that in high-transmission settings, malaria control in early childhood (
Basic Research in Infection Biology | Swiss TPH (Page)
https://www.swisstph.ch/en/research/basic-research-in-infection-biology
so-called neglected tropical diseases that affect the poorest communities. Malaria A gametocyte - the sexual form of Plasmodium Malaria is caused by unicellular parasites of the genus Plasmodium that are t [...] Infection Biology conduct cutting-edge basic research on infectious diseases of poverty including Malaria (caused by Plasmodium spp .), Tuberculosis (caused by Mycobacterium tuberculosis ), Buruli ulcer [...] Mycobacterium ulcerans ) and Sleeping sickness, African trypanosomiasis (caused...
Medicines Development | Research at Swiss TPH (Page)
https://www.swisstph.ch/en/about/med/medicines-development
platforms, malaria drug resistance genotyping services and the development of vaccines and treatments for tropical infectious diseases. The MDU excels in providing global genotyping services for malaria resistance [...] on diseases such as malaria, respiratory viruses, Buruli ulcer and undifferentiated febrile diseases. Our Core Competencies Our core expertise is in molecular genotyping for malaria drug resistance testing [...] testing, diagnostic development of non-invasive and innovative...
COVID-19: Have we learned anything from previous lessons? (Page)
https://www.swisstph.ch/en/impact-stories/covid-19-have-we-learned-anything-from-previous-lessons
SARS-CoV-2, but the increase in malaria transmission now observed in many African countries is closely linked to the pandemic. The gains made over the past two decades in malaria control are now at risk. Linking [...] diseases, especially in remote areas, went untreated. It is estimated that 500,000 more people died of malaria and pneumonia during the Ebola epidemic than on average. This is known as "collateral damage." Worsening [...] overburdening fragile health systems: the negative effects...
VectorDisk: a microfluidic platform integrating diagnostic markers for evidence-based mosquito control (Publications)
identify mosquito and malaria parasite species as well as insecticide resistance mechanisms. In the second study, purified nucleic acids served as samples to test arboviral and malaria infective mosquito