Identification of a cis-acting DNA-protein interaction implicated in singular var gene choice in <em>Plasmodium falciparum</em> (Publications)
Plasmodium falciparum is responsible for the most severe form of malaria in humans. Antigenic variation of P. falciparum erythrocyte membrane protein 1 leads to immune evasion and occurs through switc
Living near main streets and respiratory symptoms in adults (Publications)
The Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA), conducted in 1991 (SAPALDIA 1) in eight areas among 9,651 randomly selected adults aged 18-60 years, reported associatio
Successful booster antibody response up to 54 months after single primary vaccination with virosome-formulated, aluminum-free hepatitis A vaccine (Publications)
This study demonstrates that a booster dose of the virosome-formulated, aluminum-free hepatitis A vaccine Epaxal (Berna Biotech) is highly immunogenic in subjects who received a single primary dose of
Relationship between prevalence and intensity of <em>Plasmodium falciparum</em> infection in natural populations of <em>Anopheles</em> mosquitoes (Publications)
Wild-caught Anopheles gambiae s. l. and An. funestus were dissected and their midguts were examined for the presence of Plasmodium falciparum oocyst infections. The mean intensity of infection and the
Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase (Publications)
Novel quinazoline-type compounds were designed as inhibitors of the parasite specific enzyme trypanothione reductase (TR), and their biological activities were evaluated. Some of our compounds inhibit
Influence of HIV-related immunodeficiency on the risk of hepatocellular carcinoma (Publications)
OBJECTIVE: To investigate HIV-related immunodeficiency as a risk factor for hepatocellular carcinoma (HCC) among persons infected with HIV, while controlling for the effect of frequent coinfection wit