Activity of diimidazoline amides against <em>African trypanosomiasis</em> (Publications)
We identified several diimidazoline mono- and diamides that were as potent as pentamidine against Trypanosoma brucei rhodesiense in vitro. All of these were also less cytotoxic than pentamidine, but n
<em>Paragonimus paishuihoensis</em> metacercariae in freshwater crabs, <em>Potamon lipkei</em>, in Vientiane Province, Lao PDR (Publications)
Among Paragonimus species, P. paishuihoensis is one of the most mysterious and poorly understood species. Metacercariae are characterized by having a unique dendritically branched excretory bladder. H
A broadly-protective vaccine against meningococcal disease in sub-Saharan Africa based on generalised modules for membrane antigens (GMMA) (Publications)
INTRODUCTION: Neisseria meningitidis causes epidemics of meningitis in sub-Saharan Africa. These have mainly been caused by capsular group A strains, but W and X strains are increasingly contributing
Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II (Publications)
Occupational exposure is a well-recognised modifiable risk factor for asthma, but the relationship between occupational exposure and asthma control has not been studied. We aimed to study this associa
Immunoglobulin A and immunoglobulin G antibodies against beta-lactoglobulin and gliadin at age 1 associate with immunoglobulin E sensitization at age... (Publications)
BACKGROUND: Serum immunoglobulin A (IgA) and immunoglobulin G (IgG) antibodies against wheat gliadin and cow's milk beta-lactoglobulin (BLG) are considered markers of gut permeability and inflammation
Lymphatic filariasis and onchocerciasis prevention, treatment, and control costs across diverse settings: a systematic review (Publications)
The control and eventual elimination of neglected tropical disease (NTD) requires the expansion of interventions such as mass drug administration (MDA), vector control, diagnostic testing, and effecti
2,4-diaminothienopyrimidines as orally active antimalarial agents (Publications)
A novel series of 2,4-diaminothienopyrimidines with potential as antimalarials was identified from whole-cell high-throughput screening of a SoftFocus ion channel library. Synthesis and structure-acti
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1 (Publications)
A novel class of imidazopyridazines identified from whole cell screening of a SoftFocus kinase library was synthesized and evaluated for antiplasmodial activity against K1 (multidrug resistant strain)
Transcriptomic and lipidomic profiles of glycerolipids during <em>Arabidopsis</em> flower development (Publications)
Flower glycerolipids are the yet-to-be discovered frontier of the lipidome. Although ample evidence suggests important roles for glycerolipids in flower development, stage-specific lipid profiling in
