Clinical trials in low-resource settings: the perspectives of caregivers of paediatric participants from Uganda, Tanzania and Kenya (Publications)
study investigates the experience of caregivers consenting on behalf of paediatric participants in a malaria vaccine clinical trial where participation enables access to free, high-quality medical care. METHODS: [...] interviewed a total of 78 caregivers of paediatric participants previously enrolled in a phase II or III malaria vaccine clinical trial in Uganda, Tanzania and Kenya. Interviews were qualitative and analysed using
Can trials of spatial repellents be used to estimate mosquito movement? (Publications)
Knowledge of mosquito movement would aid the design of effective intervention strategies against malaria. However, data on mosquito movement through mark-recapture or genetics studies are challenging to [...] method may supplement those from mark-release-recapture studies, and be used in designing effective malaria intervention strategies, parameterizing mathematical models and in designing trials of vector control
Synthesis of antimalarial 1,2,4-trioxanes via photooxygenation of a chiral allylic alcohol (Publications)
series of monocyclic and spirobicyclic 1,2,4-trioxanes (5, 6). Two products show significant anti-Malaria activity against Plasmodium falciparum when compared with chloroquine
Blood transfusion for severe anaemia in children in a Kenyan hospital [Research letter] (Publications)
Severe anaemia often secondary to malaria is a major contributor to child mortality in sub-Saharan Africa. We have confirmed that use of simple clinical and laboratory criteria can identify those children
Diaryl ureas as an antiprotozoal chemotype (Publications)
kinetic aq. solubilities were /=10. One N,N'-diarylurea had demonstrable activity in mouse models of malaria and toxoplasmosis.
A paradigm for Africa-centric vaccine development in Equatorial Guinea (Publications)
The Equatorial Guinea Malaria Vaccine Initiative (EGMVI) highlights how long-term African government and international energy industry investment, plus novel partnerships, can enable clinical development
L'efficacité c'est bien, l'impact c'est top! (Publications)
our own experience is given to illustrate the reduction of the effect of an intervention against malaria in young children at different stages of the development of the intervention, and the parallel decrease
<em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> genotypes and efficacy of intermittent preventive treatment in Papua New Guinea (Publications)
Intermittent preventive treatment of infants (IPTi) reduces early-childhood malaria-related morbidity. While genotypic drug resistance markers have proven useful in predicting the efficacy of antimalarial
Bayesian Modelling and Analysis (Page)
https://www.swisstph.ch/en/about/eph/biostatistics/bayesian-modelling-and-analysis
Group | Bayesian Modelling and Analysis Predicted Risk Map of Malaria Parasite among Children under 5 year in Nigeria Epidemiology and Public Health Biostatistics Biostatistics Frequentist modelling Bayesian [...] research area of the group. It involves developing data-driven statistical methods and applications for malaria, neglected infectious diseases, cancer and mortality to obtain spatially explicit estimates of disease [...] Science Related Activities Research Services Related Topics...
Characterization of novel antimalarial compound ACT-451840: preclinical assessment of activity and dose-efficacy modeling (Publications)
cycle stages of the human malaria parasite Plasmodium falciparum (asexual and sexual) and Plasmodium vivax (asexual) as well as oral in vivo efficacies in two murine malaria models that permit infection [...] determination of the dose-efficacy relationship of ACT-451840 under curative conditions in rodent malaria models allowed prediction of the human efficacious exposure. CONCLUSION: The dual activity of ACT-451840