Antigenicity and immunogenicity of a novel <em>Plasmodium vivax</em> circumsporozoite derived synthetic vaccine construct (Publications)
BACKGROUND: The circumsporozoite (CS) protein is a major malaria sporozoite surface antigen currently being considered as vaccine candidate. Plasmodium vivax CS (PvCS) protein comprises a dimorphic central [...] VK210 and VK247. We studied the natural immune response to this region in human sera from different malaria-endemic areas and its immunogenicity in mice. RESULTS: PvNR1R2 was more frequently recognized by
Combating poor‑quality anti‑malarial medicines: a call to action (Publications)
medicines appear to have been particularly compromised and present a major public health threat in malaria-endemic countries, negatively affecting individuals and their communities. Concerted collaborative [...] their actions in these critical areas and thus effectively support global health development and malaria elimination programmes.
Vaccination with virosomally formulated recombinant CyRPA elicits protective antibodies against<em> Plasmodium falciparum</em> parasites in... (Publications)
emerged as a promising blood-stage candidate antigen for inclusion into a broadly cross-reactive malaria vaccine. This highly conserved protein among various geographical strains plays a key role in the [...] falciparum merozoites, and antibodies against PfCyRPA can efficiently prevent the entry of the malaria parasites into red blood cells. The aim of the present study was to develop a humancompatible formulation
Attractive toxic sugar baits for controlling mosquitoes: a qualitative study in Bagamoyo, Tanzania (Publications)
BACKGROUND: Malaria elimination is unlikely to be achieved without the implementation of new vector control interventions capable of complementing insecticide-treated nets and indoor residual spraying [...] and provides important information for future trials investigating the efficacy of ATSBs against malaria. This new vector control tool will require sensitization at community level regarding its mode of
The three <em>Plasmodium falciparum </em>Aurora-related kinases display distinct temporal and spatial associations with mitotic structures in asexual... (Publications)
Aurora kinases are crucial regulators of mitotic cell cycle progression in eukaryotes. The protozoan malaria parasite Plasmodium falciparum replicates via schizogony, a specialised mode of cell division ch [...] throughout schizogony as well as in the non-dividing gametocyte stages, which are essential for malaria transmission. We demonstrate that all three PfARKs display distinct and highly specific and exclusive
Changes in metabolic phenotypes of <em>Plasmodium falciparum</em> <em>in vitro</em> cultures during gametocyte development (Publications)
s are the Plasmodium life stage that is solely responsible for malaria transmission. Despite their important role in perpetuating malaria, gametocyte differentiation and development is poorly understood
Improving methods for analysing anti-malarial drug efficacy trials: molecular correction based on length-polymorphic markers <em>msp</em>-1,... (Publications)
BACKGROUND: Drug efficacy trials monitor the continued efficacy of front-line drugs against falciparum malaria. Over-estimates of efficacy result in a country retaining a failing drug as first-line treatment [...] modelling to simulate parasite dynamics and genetic signals that occur in patients enrolled in malaria drug clinical trials. We compared estimates of treatment failure obtained from a selection of proposed
Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity (Publications)
nt strain of Plasmodium falciparum, and examples 7 and 8 were active in vivo in mouse models of malaria
Ancistroheynine B and two further 7,3'-coupled naphthylisoquinoline alkaloids from<em> Ancistrocladus heyneanus</em> Wall (Publications)
c, and chiroptical methods. Biological activities of ancistroheynine B against the pathogens of malaria, leishmaniasis, Chagas' disease, and African sleeping sickness were evaluated
Synthesis of novel diazabicycles and their antiprotozoal activities (Publications)
potencies against Plasmodium falciparum K-1 and Trypanosoma b. rhodesiense, the causative organisms of malaria tropica and the East African form of sleeping sickness