A systematic literature review of microscopy methods reported in malaria clinical trials (Publications)
Microscopy of stained blood films is essential for the diagnosis of malaria, differentiation of parasite species, and estimation of parasite density performed for assessments of antimalarial drug efficacy [...] the emergence or spread of antimalarial drug resistance. Although evidence-based guidelines for malaria microscopy methods exist, the age-old microscopy techniques for parasitological assessments are subject
Sub-lethal aquatic doses of pyriproxyfen may increase pyrethroid resistance in malaria mosquitoes (Publications)
and Anopheles species. We examined whether PPF added to larval habitats of pyrethroid-resistant malaria vectors can modulate levels of resistance among emergent adult mosquitoes. METHODOLOGY: Third-instar
Priority setting in HIV, tuberculosis, and malaria - new cost-effectiveness results from WHO-CHOICE (Publications)
cost-effectiveness of the selected interventions. Impact modelling was performed using the OpenMalaria platform for malaria and using the Goals and TIME (TB Impact Model and Estimates) models in Spectrum for HIV [...] interventions for HIV, TB and malaria were cost-effective, with cost-effectiveness ratios less than I$ 100/HLY saved for virtually all interventions included. HIV, TB and malaria prevention and treatment [...] the 21st century (2000-2010) with respect to allocative efficiency in...
Identification and profiling of a novel diazaspiro[3.4]octane chemical series active against multiple stages of the human malaria parasite... (Publications)
A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycl
Real-time dispersal of malaria vectors in rural Africa monitored with lidar (Publications)
observation of mosquito behavior with high spatio-temporal resolution limits progress towards improved malaria vector control. We deployed a high-resolution entomological lidar to monitor a half-kilometer static [...] this study demonstrate how lidar-based monitoring could dramatically improve our understanding of malaria vector ecology and control options.
Multisectoral approach to support use of insecticide-treated net for malaria prevention among mobile and migrant populations in Myanmar: a systematic... (Publications)
BACKGROUND: Myanmar is a premalaria elimination country with artemisinin-resistant malaria. A strategy for transmission control is focused on vulnerable groups such as mobile and migrant populations (MMPs) [...] (MSA). METHODS: This narrative systematic review addressed MSAs targeted to MMPs in Myanmar for malaria prevention. We searched relevant studies in electronic databases and present the narrative findings
Study protocol of a cluster randomized controlled trial of strategies to increase antenatal iron and folic acid supplementation and malaria... (Publications)
post-partum anaemia and malaria infection. Anaemia will be assessed using HEMOCUE devices; malaria infections will be assessed using standard rapid diagnostic tests named CareStart Malaria Pf (HRP2) Ag RDT (Multi [...] of antenatal iron and folic acid supplementation (IFAS) and intermittent preventive treatment of malaria in pregnancy (IPTp) remains low in many countries. Evidence on the most effective ways to increase [...] cost, impact and relative cost-effectiveness of two complementary...
Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of <em>Plasmodium falciparum</em> malaria (Publications)
and perpetual increase in malaria incidence necessitates the development of novel anti-malarials. Histone deacetylases (HDAC) has been shown to be a promising target for malaria, despite this, there are [...] are no HDAC inhibitors in clinical trials for malaria treatment. This can be attributed to the poor pharmacokinetics, bioavailability and selectivity of the HDAC inhibitors. METHODS: A collection of HDAC [...] orally and subcutaneously. CONCLUSION: FNDR-20123 may be a suitable candidate for...