Analogues of thiolactomycin as potential antimalarial agents (Publications)
fatty acid synthase, were synthesized and evaluated for their ability to inhibit the growth of the malaria parasite Plasmodium falciparum. Alkylation of the C4 hydroxyl group led to the most significant increase
Strategies for conducting <em>Anopheles stephensi </em>surveys in non-endemic areas (Publications)
Anopheles stephensi, a malaria vector species previously only known from Asia, was first detected in Africa in Djibouti in 2012, has been subsequently collected in Ethiopia, Sudan, and Somalia, and may
A Programmatic Analysis of integrated Community Case Management (iCCM): A Multicountry Systems-Wide Analysis of the RAcE (Rapid Access Expansion) iCCM... (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/a-programmatic-analysis-of-integrated-community-case-management-iccm-a-multicountry-systems-wide-analysis-of-the-race-rapid-access-expansion-iccm-programme-in-sub-saharan-africa
provide children living in remote areas with access to case management for pneumonia, diarrhea, and malaria at the community level. The Rapid Access Expansion Programme (RAcE), steered by the World Health
Differential infectivity of Plasmodium for mosquitoes (Publications)
The four human malarias - Plasmodium falciparum, P. vivax, P. ovale and P. malariaecan - canonly be transmitted by mosquitoes of the genus Anopheles, although not all species (nor all strains) of these
Potent antimalarials with development potential identified by structure-guided computational optimization of a pyrrole-based dihydroorotate... (Publications)
DHODH inhibitors have great potential for use in prophylaxis, which represents an unmet need in the malaria drug discovery portfolio for endemic countries, particularly in areas of high transmission in Africa
Cytochrome P450-mediated metabolism and CYP Inhibition for the synthetic peroxide antimalarial OZ439 (Publications)
OZ439 is a potent synthetic ozonide evaluated for the treatment of uncomplicated malaria. The metabolite profile of OZ439 was characterized in vitro using human liver microsomes combined with LC/MS-MS
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to <em>Plasmodium falciparum</em> parasite resistance (Publications)
mode of action. This preclinical candidate may offer the potential for a single low-dose cure for malaria.
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a softfocus kinase library: part 2 (Publications)
for antiplasmodial activity against NF54 (sensitive) and K1 (multidrug resistant) strains of the malaria parasite Plasmodium falciparum and evaluated for both aqueous solubility and metabolic stability
Synthesis and in vitro and in vivo evaluation of antimalarial polyamines (Publications)
falciparum. In an effort to expand the structure-activity relationship of this compound class towards malaria, we have prepared and biologically tested a library that includes benzamide and 3-phenylpropanamide
Trypanocidal activity of diarylheptanoids from <em>Schrankia leptocarpa</em> DC (Publications)
Schrankia leptocara is a medicinal species use traditionally in Benin to treat malaria. A previous study showed interesting antimalarial activity against two strains of Plasmodium falciparum. Phytochemical