<em>Plasmodium falciparum </em>malaria disease manifestations in humans and transmission to<em> Anopheles gambiae</em>: a field study in Western Kenya (Publications)
Transmission of the malaria parasite Plasmodium is influenced by many different host, vector and parasite factors. Here we conducted a field study at Mbita, an area of endemic malaria in Western Kenya, to [...] to test whether parasite transmission to mosquitoes is influenced by the severity of malaria infection in its human host at the time when gametocytes, the transmission forms, are present in the peripheral [...] Plasmodium falciparum gametocyte carriers to mosquitoes. Of these, 21 were...
Inhibition of dendritic cell maturation by malaria is dose dependent and does not require<em> Plasmodium falciparum</em> erythrocyte membrane protein... (Publications)
Red blood cells infected with Plasmodium falciparum (iRBCs) have been shown to modulate maturation of human monocyte-derived dendritic cells (DCs), interfering with their ability to activate T cells.
Antibody and T cell responses associated with experimental human malaria infection or vaccination show limited relationships (Publications)
examined specific antibody and T cell responses associated with experimental malaria infection or malaria vaccination, in malaria-naive human volunteers within phase I/IIa vaccine trials, with a view to [...] investigating inter-relationships between these types of response. Malaria infection was via 5 bites of Plasmodium falciparum-infected mosquitos, with individuals reaching patent infection by 11-12 days [...] class switching was seen from an early IgM to an IgG1-dominant response of...
Design of a phase III cluster randomized trial to assess the efficacy and safety of a malaria transmission blocking vaccine (Publications)
falciparum malaria transmission targeting sexual, sporogonic, or mosquito-stage antigens (SSM-VIMT) are currently under development to reduce malaria transmission. An international group of malaria experts [...] estimates suggest that such a trial is feasible, and within the range of previously supported trials of malaria interventions, although substantial issues to implementation exist.