Blood schizontocidal and gametocytocidal activity of 3-hydroxy-N'-arylidenepropanehydrazonamides: a new class of antiplasmodial compounds (Publications)
moiety, demonstrated in vivo antiplasmodial activity after oral administration in a P. berghei malaria model, although no complete parasite elimination was achieved with a four-dose regimen. The in vivo
Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals (Publications)
such as the semisynthetic artemisinins are critically important in the treatment of drug-resistant malaria. Nevertheless, their peroxide bond-dependent mode of action is still not well understood. Using
<em>Plasmodium falciparum Plasmodium</em> helical interspersed subtelomeric proteins contribute to cytoadherence and anchor <em>P. falciparum</em>... (Publications)
endothelium is conferred through the parasite-derived virulence factor PfEMP1, the major contributor to malaria severity. PfEMP1 located at knob structures on the erythrocyte surface is anchored to the cytoskeleton
Indole and benzimidazole bichalcophenes: synthesis, DNA binding and antiparasitic activity (Publications)
their antimicrobial activity against the tropical parasites causing African sleeping sickness and malaria. The dicyanoindoles needed to synthesize the target diamidines were obtained through Stille coupling
Günther Fink (People)
https://www.swisstph.ch/en/staff/profile/people/guenther-fink
programs in Nigeria, and large-scale private and public sector initiatives to reduce the burden of malaria in Angola, Namibia, Uganda and Zambia. He is currently the PI of the Zambia Early Childhood Development
Farewell to Thierry Freyvogel (News)
https://www.swisstph.ch/en/news/news-detail/news/farewell-to-thierry-freyvogel
influence on him throughout his life. The enormous malaria transmission around Ifakara drove Thierry Freyvogel to new scientific findings on malaria on the one hand and deepened his understanding of the
A project testing whether small solar powered electric fans improve comfort inside mosquito nets (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/a-project-testing-whether-small-solar-powered-electric-fans-improve-comfort-inside-mosquito-nets
Background Long-lasting insecticidal nets (LLINs) are ineffective malaria transmission prevention tools if they are unused. Discomfort due to heat is the most commonly reported reason for not using nets [...] price of solar power, fans could improve comfort inside nets and be affordable to populations in malaria endemic areas. Here, results are presented from a pilot randomized controlled cross-over study testing
Summer Symposium 2018 (Page)
https://www.swisstph.ch/en/about/events/summer-symposium-2018
Clinical Research Worlds – Approaches and Challenges Moderator: Wiweka Kaszubska, Medicines for Malaria Venture, Geneva, Switzerland 11:15 The Big Pharma Approach and Future Developments, Anthony Man, [...] Clinical Practice, Brussels, Belgium 14:00 Working in a PDP Business Model, David Reddy, Medicines for Malaria Venture, Geneva, Switzerland 14:30 The Future of Drug Development, Djordje Filipovic, Novartis I
Comparative functional survival and equivalent annual cost of 3 long-lasting insecticidal net (LLIN) products in Tanzania: a randomised trial with... (Publications)
BACKGROUND: Two billion long-lasting insecticidal nets (LLINs) have been procured for malaria control. A functional LLIN is one that is present, is in good physical condition, and remains insecticidal [...] monitor their comparative durability to ensure that the most cost-effective products are procured for malaria control.
<em>In vitro</em> antiplasmodial activity and cytotoxicity of extracts and chromatographic fractions of twigs from <em>Pappea capensi</em>s EckI &... (Publications)
The Vha-Venda people of South Africa use Pappea capensis EckI & Zeyh. (Sapindaceae) twigs to treat malaria and its related symptoms. AIM OF STUDY: The main aim of this study was to evaluate the antiplasmodial [...] in P. capensis twigs. CONCLUSION: The study validates the ethnomedicinal use of P. capensis for malaria treatment. It demonstrated the potential of discovering novel antiplasmodial constituents that could