Malaria risk and access to prevention and treatment in the paddies of the Kilombero Valley, Tanzania (Publications)
BACKGROUND: The Kilombero Valley is a highly malaria-endemic agricultural area in south-eastern Tanzania. Seasonal flooding of the valley is favourable to malaria transmission. During the farming season, many [...] nearest health services. This study assessed the impact of seasonal movements to remote fields on malaria risk and treatment-seeking behaviour. METHODS: A longitudinal study followed approximately 100 randomly [...] fever-risk. Mosquito nets usage and treatment of fever in health...
Rifampicin/Cotrimoxazole/Isoniazid versus mefloquine or quinine + sulfadoxine- pyrimethamine for malaria: a randomized trial1 (Publications)
multicentric noninferiority trial to assess the safety and efficacy of Cotrifazid against drug-resistant malaria in Papua New Guinea. DESIGN: The trial design was open-label, block-randomised, comparative, and [...] Sepik Province, Papua New Guinea. PARTICIPANTS: Patients of all ages with recurrent uncomplicated malaria were included. INTERVENTIONS: Patients were randomly assigned to receive Cotrifazid, mefloquine, [...] makes Cotrifazid in its current formulation and regimen a poor alternative...
Malaria and its possible control on the island of Príncipe (Publications)
BACKGROUND: Malaria can be eradicated from islands. To assess the prospects for eradication of malaria from the island of Príncipe in the Gulf of Guinea, we fitted a mathematical model to age-prevalence [...] nets and mosquito-proofing of dwellings. In contrast to traditional malaria eradication strategies, this would avoid the risk of malaria epidemics because the reduction in R0 should be sustainable. [...] thus obtained estimates of the vectorial capacity and of the basic reproductive number...
MalariaSphere: a greenhouse-enclosed simulation of a natural <em>Anopheles gambiae</em> (Diptera: Culicidae) ecosystem in western Kenya (Publications)
BACKGROUND: The development and implementation of innovative vector control strategies for malaria control in Africa requires in-depth ecological studies in contained semi-field environments. This particularly [...] to significantly enhance our understanding of the behavioural and evolutionary ecology of African malaria vectors and our ability to develop and evaluate innovative control strategies. With regard to ge
Do health workers' preferences influence their practices? Assessment of providers' attitude and personal use of new treatment recommendations for... (Publications)
Tanzania changed malaria treatment policies twice within a decade. First in 2001 chloroquine (CQ) was replaced by sulfadoxine-pyrimethamine (SP) for management of uncomplicated malaria and by late 2006 [...] by enquiring which antimalarial was considered most suitable for the management of uncomplicated malaria for the three patient categories: i) children below 5; ii) older children and adults; and iii) pregnant [...] pregnant women. Practice was ascertained by asking which antimalarial was...
Dynamics of socioeconomic risk factors for neglected tropical diseases and malaria in an armed conflict (Publications)
and assessed the dynamics of socioeconomic risk factors for neglected tropical diseases (NTDs) and malaria. METHODOLOGY: The same standardized and pre-tested questionnaires were administered to the heads [...] anecdotal evidence point toward a relationship between an increased risk of suffering from NTDs and malaria and armed conflict. CONCLUSION: New research is needed to deepen our understanding of the often diffuse
Cell biological characterization of the malaria vaccine candidate trophozoite exported protein 1 (Publications)
extensive preclinical evaluation of its coiled coil peptides Tex1 was identified as promising novel malaria vaccine candidate providing the rational for a comprehensive cell biological characterization of
Quantifying behavioural interactions between humans and mosquitoes: Evaluating the protective efficacy of insecticidal nets against malaria... (Publications)
ABSTRACT: BACKGROUND: African malaria vectors bite predominantly indoors at night so sleeping under an Insecticide-Treated Net (ITN) can greatly reduce malaria risk. Behavioural adaptation by mosquitoes [...] allow vector mosquitoes to bite outside of peak sleeping hours and undermine efficacy of this key malaria prevention measure. METHODS: High coverage with largely untreated nets has been achieved in the Kilombero [...] peak sleeping hours, respectively. ITNs consistently conferred > 70%...
Spatio-temporal analysis of the role of climate in inter-annual variation of malaria incidence in Zimbabwe (Publications)
inter-annual variation in malaria incidence. Quantitative description of the space-time effect of this association has practical implications for the development of operational malaria early warning system [...] system (MEWS) and malaria control. We used Bayesian negative binomial models for spatio-temporal analysis of the relationship between annual malaria incidence and selected climatic covariates at a district level [...] 1988-1999. RESULTS: Considerable inter-annual variations were observed...
Target product profile choices for intra-domiciliary malaria vector control pesticide products: repel or kill? (Publications)
BACKGROUND: The most common pesticide products for controlling malaria-transmitting mosquitoes combine two distinct modes of action: 1) conventional insecticidal activity which kills mosquitoes exposed [...] mosquitoes to non-users rather than killing them outright. METHODS: A process-explicit model of malaria transmission is described which captures the sequential interaction between deterrent and toxic actions
