Soudanones A-G: antifungal isochromanones from the ascomycetous fungus <em>Cadophora</em> sp. isolated from an iron mine (Publications)
One new isochromane (pseudoanguillosporin C, 2), seven isochromanones (soudanones A-G, 3-9), and six known analogues including 10 and 11 were isolated from a culture of the fungus Cadophora sp. 10-5-2
<em>In vivo</em> biosynthesis of terpene nucleosides provides unique chemical markers of <em>Mycobacterium tuberculosis</em> infection (Publications)
Although small molecules shed from pathogens are widely used to diagnose infection, such tests have not been widely implemented for tuberculosis. Here we show that the recently identified compound, 1-
Host-directed therapies for tackling multi-drug resistant TB - learning from the Pasteur-Bechamp debates (Publications)
Tuberculosis (TB) remains a global emergency causing an estimated 1.5 million deaths annually. For several decades the major focus of TB treatment has been on antibiotic development targeting Mycobact
Towards host-directed therapies for tuberculosis [Comment] (Publications)
The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis. A new global initiative is now focusing on a complementary approach of developing adjun
The lipid-modifying enzyme SMPDL3B negatively regulates innate immunity (Publications)
Lipid metabolism and receptor-mediated signaling are highly intertwined processes that cooperate to fulfill cellular functions and safeguard cellular homeostasis. Activation of Toll-like receptors (TL
Chemical constituents from <em>Waltheria indica</em> exert <em>in vitro</em> activity against <em>Trypanosoma brucei</em> and <em>T. cruzi</em> (Publications)
Six extracts from the roots and the aerial parts of Waltheria indica L. (Malvaceae) were screened for their in vitro antitrypanosomal activity towards Trypanosoma brucei brucei STIB 427 strain, Trypan
A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes (Publications)
Discovery of novel drug targets may lead to improved treatment of trypanosomiasis. We characterize here 2 gene products of Trypanosoma brucei that are essential for the growth of bloodstream form para
Community awareness, use and preference for pandemic influenza vaccines in Pune, India (Publications)
Vaccination is a cornerstone of influenza prevention, but limited vaccine uptake was a problem worldwide during the 2009-2010 pandemic. Community acceptance of a vaccine is a critical determinant of i