Defining the relationship between infection prevalence and clinical incidence of<em> Plasmodium falciparum</em> malaria (Publications)
In many countries health system data remain too weak to accurately enumerate Plasmodium falciparum malaria cases. In response, cartographic approaches have been developed that link maps of infection p
International scale implementation of the CNOSSOS-EU road traffic noise predictin model for epidemiological studies (Publications)
The EU-FP7-funded BioSHaRE project is using individual-level data pooled from several national cohort studies in Europe to investigate the relationship of road traffic noise and health. The detailed i
Spatial distribution of schistosomiasis and treatment needs in sub-Saharan Africa: a systematic review and geostatistical analysis (Publications)
BACKGROUND: Schistosomiasis affects more than 200 million individuals, mostly in sub-Saharan Africa, but empirical estimates of the disease burden in this region are unavailable. We used geostatistica
Quantifying the health impacts of ambient air pollutants: recommendations of a WHO/Europe project (Publications)
OBJECTIVE: Quantitative estimates of air pollution health impacts have become an increasingly critical input to policy decisions. The WHO project "Health risks of air pollution in Europe-HRAPIE" was i
ARMADA: using motif activity dynamics to infer gene regulatory networks from gene expression data (Publications)
Analysis of gene expression data remains one of the most promising avenues toward reconstructing genome-wide gene regulatory networks. However, the large dimensionality of the problem prohibits the fi
Transport-related measures to mitigate climate change in Basel, Switzerland: a health-effectiveness comparison study (Publications)
BACKGROUND: Local strategies to reduce green-house gases (GHG) imply changes of non-climatic exposure patterns. OBJECTIVE: To assess the health impacts of locally relevant transport-related climate ch
Gift from nature: cyclomarin a kills mycobacteria and malaria parasites by distinct modes of action (Publications)
Malaria continues to be one of the most devastating human diseases despite many efforts to limit its spread by prevention of infection or by pharmaceutical treatment of patients. We have conducted a s
Discovery and optimisation studies of antimalarial phenotypic hits (Publications)
There is an urgent need for the development of new antimalarial compounds. As a result of a phenotypic screen, several compounds with potent activity against the parasite Plasmodium falciparum were id
Outcomes mapping study for childhood vaccination communication: too few concepts were measured in too many ways (Publications)
OBJECTIVES: The objectives of this paper are: 1) to comprehensively catalogue outcomes measured in trials of childhood vaccination communication interventions; and 2) to analyse patterns and trends in
Geographical and temporal structures of <em>Legionella pneumophila</em> sequence types in Comunitat Valenciana (Spain), 1998 to 2013 (Publications)
Legionella pneumophila is an accidental human pathogen associated with aerosol formation in water-related sources. High recombination rates make Legionella populations genetically diverse, and nearly