From magic bullet to magic bomb: reductive bioactivation of antiparasitic agents (Publications)
Paul Ehrlich coined the term "magic bullet" to describe how a drug kills the parasite inside its human host without harming the host itself. Ehrlich concluded that the drug must have a greater affinit
A household-based community health worker programme for non-communicable disease, malnutrition, tuberculosis, HIV and maternal health: a stepped-wedge... (Publications)
BACKGROUND: Community health worker (CHW) programmes are a valuable component of primary care in resource-poor settings. The evidence supporting their effectiveness generally shows improvements in dis
Design of proteasome inhibitors with oral efficacy <em>in vivo</em> against<em> Plasmodium falciparum</em> and selectivity over the human proteasome (Publications)
The Plasmodium falciparum proteasome is a potential antimalarial drug target. We have identified a series of amino-amide boronates that are potent and specific inhibitors of the P. falciparum 20S prot
The impact of health worker absenteeism on patient health care seeking behavior, testing and treatment: a longitudinal analysis in Uganda (Publications)
INTRODUCTION: Absenteeism of frontline health workers in public sector facilities is widespread in low-income countries. There is little quantitative evidence on how health worker absenteeism influenc
Changes in socioeconomic determinants of health in a copper mine development area, northwestern Zambia (Publications)
In 2011, an industrial copper mine was developed in northwestern Zambia. A health impact assessment was conducted to anticipate and address potential health impacts. To monitor these impacts, three co
Dynamics of the COVID-19 epidemic in Ireland under mitigation (Publications)
BACKGROUND: In Ireland and across the European Union the COVID-19 epidemic waves, driven mainly by the emergence of new variants of the SARS-CoV-2 have continued their course, despite various interven
