Whole-genome sieve analysis: identification of protective malaria antigens by leveraging allele-specific vaccine efficacy (Publications)
Discovery of new protective malaria antigens will enable the development of novel vaccine formulations with potentially higher efficacy. While several high-throughput experimental approaches enable the
Scalable camera traps for measuring the attractiveness of sugar baits for controlling malaria and dengue vectors (Publications)
BACKGROUND: Attractive targeted sugar baits (ATSBs) are promising new interventions that can complement existing vector control tools. However, reproducible and quantitative information on the level o
Impact of climate variability and interventions on malaria incidence and forecasting in Burkina Faso (Publications)
BACKGROUND: Malaria remains a climate-driven public health issue in Burkina Faso, yet the interactions between climatic factors and malaria interventions across different zones are not well understood [...] suitability and malaria incidence. Wavelet analysis was conducted to understand better how fluctuations in climatic factors across different time scales and climatic zones affect malaria transmission dynamics [...] . This study estimates time delays in the effects of climatic factors on malar...
Contrasting vector competence of three main East African <em>Anopheles</em> malaria vector mosquitoes for <em>Plasmodium falciparum</em> (Publications)
three malaria vector species may contribute to malaria transmission in East Africa, with An. funestus demonstrating superior vector competence. In conclusion, there is a need for comprehensive malaria control [...] control strategies targeting major malaria vector species, an update of malaria transmission models to consider vector competence and evaluation of malaria transmission blocking interventions in assays that [...] majority of malaria transmission, posing a significant public health...
Characterizing the pharmacological interaction of the antimalarial combination artefenomel-piperaquine in healthy volunteers with induced blood-stage... (Publications)
BACKGROUND: The combination antimalarial artefenomel-piperaquine failed to achieve target efficacy in a phase 2b study in Africa and Vietnam. We retrospectively evaluated whether characterizing the ph
Natural variation in timing of egg hatching, response to water agitation, and bidirectional selection of early and late hatching strains of the... (Publications)
variation in egg hatching and its environmental and genetic determinants in sibling species of the malaria vector Anopheles gambiae s.l. is important for understanding their adaptation to variable aquatic
The interspecific competition between larvae of <em>Aedes aegypti</em> and major african malaria vectors in a semi-field system in Tanzania (Publications)
Interspecific competition between mosquito larvae may affects adult vectorial capacity, potentially reducing disease transmission. It also influences population dynamics, and cannibalistic and predato