Identification of new human malaria parasite <em>Plasmodium falciparum</em> dihydroorotate dehydrogenase inhibitors by pharmacophore and... (Publications)
Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH), a key enzyme in the de novo pyrimidine biosynthesis pathway, which the Plasmodium falciparum relies on exclusively for survival, has emerg
Hemolysis after oral artemisinin combination therapy for uncomplicated <em>Plasmodium falciparum</em> malaria (Publications)
weeks after treatment of severe malaria with intravenous artesunate have been described. We performed a prospective observational study of patients with uncomplicated malaria to investigate whether posttreatment [...] occurs after oral artemisinin-based combination therapy. Eight of 20 patients with uncomplicated malaria who were given oral artemisinin-based combination therapy met the definition of posttreatment hemolysis [...] g/dL; p = 0.002). These findings indicate a need for increased...
Pregnant women and infants as sentinel populations to monitor prevalence of malaria: results of pilot study in Lake Zone of Tanzania (Publications)
screened for malaria infection using a malaria rapid diagnostic test (RDT) from December 2012 to November 2013, regardless of symptoms. Participants who tested positive were treated for malaria per national [...] BACKGROUND: As malaria control interventions are scaled-up, rational approaches are needed for monitoring impact over time. One proposed approach includes monitoring the prevalence of malaria infection among [...] facility (HF) visits. This pilot explored the feasibility and utility of...
Mapping intra-urban malaria risk using high resolution satellite imagery: a case study of Dar es Salaam (Publications)
of malaria in rapidly growing African urban settlements. The complex and heterogeneous nature of urban malaria requires a better understanding of the spatial and temporal patterns of urban malaria risk [...] localized heterogeneity of malaria transmission and develop a high resolution predictive malaria risk map of Dar es Salaam. RESULTS: Results indicate that the risk of malaria infection varied across the [...] settlements by 2030, the burden of malaria among urban populations in Africa...
Stakeholders' opinions and questions regarding the anticipated malaria vaccine in Tanzania (Publications)
accept the malaria vaccine despite the need to continue using insecticide-treated nets (ITNs), while 88.4 % reported that they will accept malaria vaccine even if their children get malaria less often [...] opinions towards malaria vaccine were due to a need for additional malaria prevention strategies and expectations that the vaccine will reduce visits to the health facility, deaths, malaria episodes and [...] BACKGROUND: Within the context of combined interventions, malaria vaccine may...
Ecological drivers of <em>Mansonella perstans</em> infection in Uganda and patterns of co-endemicity with lymphatic filariasis and malaria (Publications)
BACKGROUND: Mansonella perstans is a widespread, but relatively unknown human filarial parasite transmitted by Culicoides biting midges. Although it is found in many parts of sub-Saharan Africa, only
Low prevalence of <em>Plasmodium</em> and absence of malaria transmission in Conakry, Guinea: prospects for elimination (Publications)
to malaria have been reduced substantially in sub-Saharan Africa and local elimination has been achieved in some settings. This study addresses the bio-ecology of larval and adult stages of malaria vectors [...] using the VecTest malaria panel assay and an enzyme-linked immunosorbent assay. A systematic research of Ministry of Health statistical yearbooks was performed to determine malaria prevalence in children [...] infection in Anopheles gambiae s.l. in the city of Conakry, Guinea, and...
Spatially variable risk factors for malaria in a geographically heterogeneous landscape, western Kenya: an explorative study (Publications)
factors for malaria can give insight into which human and environmental characteristics play important roles in sustaining malaria transmission. METHODS: On Rusinga Island, western Kenya, malaria infection [...] negatively associated with malaria prevalence. DISCUSSION: Identification of risk factors for malaria that vary geographically can provide insight into the local epidemiology of malaria. Examining spatially [...] Combining the data from both surveys, overall malaria prevalence was 24 %....
Community-based surveillance to monitor mortality in a malaria-endemic and Ebola-epidemic setting in rural Guinea (Publications)
a reinforced malaria control program and one sous-prefecture without (Koundou) in Guinea. Deaths were recorded by key informants and classified as due to malaria or another cause. Malaria deaths were those [...] deaths were reported from July 2011-June 2014, of which 55.2% (N = 686) were reported as due to malaria. Malaria-attributable proportional mortality decreased by 26.5% (95% confidence interval [CI] = 13.9-33 [...] those reported as due to malaria or fever in the 3 days before death with...
Changes in malaria burden and transmission in sentinel sites after the roll-out of long-lasting insecticidal nets in Papua New Guinea (Publications)
exhibits a complex malaria epidemiology due to diversity in malaria parasites, mosquito vectors, human hosts, and their natural environment. Heterogeneities in transmission and burden of malaria at various scales [...] scales are likely to affect the success of malaria control interventions, and vice-versa. This manuscript assesses changes in malaria prevalence, incidence and transmission in sentinel sites following the [...] Diagnosis of malaria infection in humans was done by rapid diagnostic...
