Generation of aurachin derivatives by whole-cell biotransformation and evaluation of their antiprotozoal properties (Publications)
The natural product aurachin D is a farnesylated quinolone alkaloid, which is known to possess activity against the causative agent of malaria, Plasmodium spp. In this study, we show that aurachin D i
Diagnosis of helminths depends on worm fecundity and the distribution of parasites within hosts (Publications)
Helminth transmission and morbidity are dependent on the number of mature parasites within a host; however, observing adult worms is impossible for many natural infections. An outstanding challenge is
Efficacy and safety of moxidectin and albendazole compared with ivermectin and albendazole coadministration in adolescents infected with <em>Trichuris... (Publications)
BACKGROUND: Control efforts against soil-transmitted helminths focus on preventive chemotherapy with albendazole and mebendazole, however these drugs yield unsatisfactory results against Trichuris tri
Genetically modified malaria parasites as vaccine candidates (Publications)
Induction of sterile immunity against sporozoite and liver stages of malaria is a long-standing aim in vaccine development. Genetically engineered, attenuated sporozoites were systematically evaluated
A comparison of statistical and machine-learning approaches for spatiotemporal modeling of nitrogen dioxide across Switzerland (Publications)
Land use regression modeling has commonly been used to model ambient air pollutant concentrations in environmental epidemiological studies. Recently, other statistical and machine-learning methods hav
Stigma-directed services (Stig2Health) to improve 'linkage to care' for people living with HIV in rural Tanzania: study protocol for a nested pre-post... (Publications)
Background: HIV-related stigma is a major barrier to the timely linkage and retention of patients in HIV care in sub-Saharan Africa, where most people living with HIV/AIDS reside. In this implementati
Perceived water-related risk factors of Buruli ulcer in two villages of south-central Côte d’Ivoire (Publications)
Background Buruli ulcer, caused by Mycobacterium ulcerans, is a neglected tropical skin disease that is primarily endemic in West and Central Africa, including Côte d’Ivoire. Studies indicate that M.