Two cases of long‑lasting, sub‑microscopic <em>Plasmodium malariae</em> infections in adults from coastal Tanzania (Publications)
BACKGROUND: Malaria is endemic in Tanzania with majority of clinical cases caused by Plasmodium falciparum. Additionally, Plasmodium malariae and Plasmodium ovale spp. are also present and clinical ma [...] caused by P. malariae infections are often characterized by a relatively mild illness with a low number of parasites, which can persist for long periods. In this report, two cases of P. malariae infections [...] study clinical manifestations of P. malariae over 4 months. CASE PRESENTATION:...
Predicting the cost of malaria elimination in the Asia-Pacific (Publications)
decade, the countries of the Asia-Pacific region have made significant progress towards the goal of malaria elimination by the year 2030. It is widely accepted that for the region to meet this goal, an in [...] funding is required. However, robust estimates are needed for the optimal coverage and components of malaria elimination packages and the resources required to implement them. In this collection, a multispecies
Safety profile of the RTS,S/AS01 malaria vaccine in infants and children: additional data from a phase III randomized controlled trial in sub-Saharan... (Publications)
RTS,S/AS01 (R3R) or non-malaria control vaccine (C3C), or 3 RTS,S/AS01 doses plus control (R3C). Aggregate safety data were reviewed by a multi-functional team. Severe malaria with Blantyre Coma Score [...] controlled trial (NCT00866619) in sub-Saharan Africa showed RTS,S/AS01 vaccine efficacy against malaria. We now present in-depth safety results from this study. 8922 children (enrolled at 5-17 months)
Highly heterogeneous residual malaria risk in western Thailand (Publications)
substantial and poses a challenge for the national malaria elimination program. To determine epidemiological parameters as well as risk factors for malaria infection in western Thailand, we carried out a [...] Over the past decades, the malaria burden in Thailand has substantially declined. Most infections now originate from the national border regions. In these areas, the prevalence of asymptomatic infections [...] provinces on the Thailand-Myanmar border. Blood samples from 999 local...
Modeling support for BMGF Malaria Portfolio Analysis (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/modeling-support-for-bmgf-malaria-portfolio-analysis
in the malaria product portfolio of the Bill & Melinda Gates Foundation and partners. This model-based evidence combined with costs and economic analysis supports strategic decisions for malaria.
New Discovery Unravels Malaria Invasion Mechanism (News)
https://www.swisstph.ch/en/news/news-detail/news/new-discovery-unravels-malaria-invasion-mechanism
million cases of malaria and 608,000 deaths in 2022, malaria has remained an intractable global health threat. The malaria parasite Plasmodium falciparum is the leading cause of severe malaria and is responsible [...] the largest portion of malaria deaths. All clinical symptoms of malaria are caused by the multiplication of malaria parasites in the red blood cells. Key component found for malaria invasion P. falciparum [...] the species-specific targeting of malaria parasites. In this study, we...
