Lidar reveals activity anomaly of malaria vectors during pan-African eclipse (Publications)
a quarter billion people are infected and a half a million killed by the mosquito-borne disease malaria. Lack of real-time observational tools for continuously assessing the unperturbed mosquito flight [...] modulation signatures. We were able to compare the fine-scale spatiotemporal activity patterns of malaria vectors during ordinary days and an eclipse to disentangle phototactic activity patterns from the
Lead optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series for the treatment of malaria (Publications)
Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The pyrimidine biosynthetic enzyme dihydroorotate [...] dihydroorotate dehydrogenase (DHODH) is a validated target for malaria treatment based on our finding that triazolopyrimidine DSM265 (1) showed efficacy in clinical studies. Herein, we describe optimization of
Outpatient treatment of imported uncomplicated <em>Plasmodium falciparum</em> malaria: results from a survey among TropNet and GeoSentinel experts for... (Publications)
BACKGROUND: Plasmodium falciparum malaria (P.f. malaria) is frequently imported to non-endemic countries. Recommendations on outpatient treatment differ largely due to differences in country-level guidelines [...] TropNet or GeoSentinel referral centres for tropical medicine outside malaria endemic areas investigated common practices in P.f. malaria management, selection criteria for outpatient management and diagnostic [...] of the centres are located in Europe (n = 37). Overall, 27 centres...
Health systems and global progress towards malaria elimination, 2000-2016 (Publications)
progress in malaria control in the 2000-2016 period among 105 countries. Additional analysis was performed within malaria burden groups. RESULTS: There was large heterogeneity in progress in malaria control [...] BACKGROUND: As more countries progress towards malaria elimination, a better understanding of the most critical health system features for enabling and supporting malaria control and elimination is needed. METHODS: [...] with reductions in malaria burden between 2000 and 2016. In...
Epitope mapping and fine specificity of human T and B cell responses for novel candidate blood-stage malaria vaccine P27A (Publications)
novel synthetic malaria vaccine candidate derived from the blood stage Plasmodium falciparum protein Trophozoite Exported Protein 1 (TEX1/PFF0165c). In phase 1a/1b clinical trials in malaria unexposed adults [...] adults in Switzerland and in malaria pre-exposed adults in Tanzania, P27A formulated with Alhydrogel and GLA-SE adjuvants induced antigen-specific antibodies and T-cell activity. The GLA-SE adjuvant induced
Malaria elimination transmission and costing in the Asia-Pacific: developing an investment case (Publications)
the regional goal of malaria elimination by 2030 will require an intensification of efforts and a plan for sustainable financing. This article presents an investment case for malaria elimination to facilitate [...] billion. Malaria elimination provides a 6:1 return on investment. Conclusion: This investment case provides compelling evidence for the benefits of continued prioritization of funding for malaria and can [...] Background: The Asia-Pacific region has made significant progress against m...
Swiss TPH Designated WHO Collaborating Centre for its Expertise in Malaria (News)
https://www.swisstph.ch/en/news/news-detail/news/swiss-tph-designated-who-collaborating-centre-for-its-expertise-in-malaria
Alonso, Director of the WHO Global Malaria Programme. “The institutes’ long-term expertise in malaria research, control and elimination will be highly valuable in supporting WHO’s capacity to implement [...] spraying that are aimed at preventing malaria to support the development of updated WHO policy guidance. The agreement also acknowledges Swiss TPH’s efforts to advance malaria control and elimination through [...] An Expert Hub for Malaria Following years of fruitful collaboration, the Swiss...
The Achilles Heel of Plasmodia - Advances in Vaccine Development against Malaria (News)
https://www.swisstph.ch/en/news/news-detail/news/the-achilles-heel-of-plasmodia-advances-in-vaccine-development-against-malaria
To date, there is no highly effective vaccination against malaria available. In collaboration with Joerg Benz and Markus Rudolph from the Roche Structural Biologie Unit, the Swiss TPH research group headed [...] Hidden Antigens The variability of antigens is a major problem in the development of vaccines against malaria. Most plasmodial surface proteins differ greatly among the various Plasmodia strains. For this reason [...] on the surface of virus-like particles (virosomes). In a clinical...
