The <em>Plasmodium falciparum</em> Hsp70-x chaperone assists the heat stress response of the malaria parasite (Publications)
Plasmodium falciparum is the most lethal of human-infective malaria parasites. A hallmark of P. falciparum malaria is extensive remodeling of host erythrocytes by the parasite, which facilitates the d [...] Vakonakis, I. The Plasmodium falciparum Hsp70-x chaperone assists the heat stress response of the malaria parasite.
Safety and immunogenicity of the RTS,S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in... (Publications)
BACKGROUND: We assessed the safety and immunogenicity of the RTS,S/AS01 malaria vaccine in a subset of children identified as HIV-infected during a large phase III randomized controlled trial conducted
The development and evaluation of a self-marking unit to estimate malaria vector survival and dispersal distance (Publications)
diseases such as malaria. Mosquito mark-release-recapture (MMRR) experiments are a popular method of measuring the survival and dispersal of disease vectors; however, examples with African malaria vectors are [...] This study demonstrates the successful use of a self-marking device in an MMRR study with African malaria vectors. This method may be useful in investigating population structure and dispersal of mosquitoes
Multi-Insecticide Resistant Malaria Vectors Remain Susceptible to Malathion Insecticide (News)
https://www.swisstph.ch/en/news/news-detail/news/multi-insecticide-resistant-malaria-vectors-remain-susceptible-to-malathion-insecticide
Despite ongoing efforts in malaria control, the progress of malaria prevention has remained stagnant over the past seven years. The World Health Organization estimates a rise in malaria cases from 227 million [...] role in recent years, progress in malaria control was already stalling; with one reason being the increase in insecticide resistance. The main tools in fighting malaria and other vector-borne diseases are [...] indoor residual spraying. The extensive use of insecticides in vector...
Analysis of 20 Years Finds Malaria Control in Young Children Saves Lives into Adulthood (News)
https://www.swisstph.ch/en/news/news-detail/news/analysis-of-20-years-finds-malaria-control-in-young-children-saves-lives-into-adulthood
particularly unusual and provides unique insight into the long-term benefits of malaria control in young children. Malaria killed more than 600,000 people in 2020 and is especially dangerous for children [...] bites. In malaria-endemic areas, sleeping under a bed net treated with insecticide is one of the most effective ways to protect young lives. Until now, however, the long-term effect of malaria control in [...] in early childhood has been unclear. Theory suggested that preventing malaria in...
First Malaria Vaccine Recommended for Children by the WHO (News)
https://www.swisstph.ch/en/news/first-malaria-vaccine-recommended-for-children
disease,” said Christian Lengeler, a malaria epidemiologist at Swiss TPH and President of the Swiss Malaria Group. “With a moderate efficacy of 30% of severe malaria cases, the new vaccine still makes a [...] of the five malaria pathogens and the most common in Africa. Swiss TPH has played a leading role in this day coming to fruition thanks to decades of research and development of new malaria vaccines. R [...] RTS,S, produced by GlaxoSmithKline (GSK), belongs to a first generation of malaria...
Swiss TPH Re-designated as WHO Collaborating Centre for Expertise in Malaria (News)
https://www.swisstph.ch/en/news/who-collaborating-centre-for-expertise-in-malaria
world free from malaria." An expert hub for malaria Within the Collaborating Centre, Swiss TPH will improve modelling methodologies that contribute towards malaria prevention and advance malaria control and [...] WHO Global Malaria Programme. "The institute's long-term expertise in malaria research, control and elimination will be highly valuable in supporting the WHO to implement its work on malaria prevention [...] Monitoring and Training for Malaria Control and Elimination The Collaborating...
Shaping the Next-generation of Interventions for Malaria Prevention (News)
https://www.swisstph.ch/en/news/news-detail/news/shaping-the-next-generation-of-interventions-for-malaria-prevention
substantially reducing the number of malaria cases since 2000, malaria remains a major public health concern. In 2019, there were an estimated 229 million cases of malaria worldwide according to the World [...] (WHO). Worryingly, in some countries, malaria is even on the rise. Children under five are particularly vulnerable. In 2019, they accounted for 67% (274,000) of all malaria deaths worldwide. Pregnant women [...] for malaria prevention. The project aims to fill the gaps that still remain...
Mathematical Modelling to Inform Next-Generation Malaria Interventions (News)
https://www.swisstph.ch/en/news/news-detail/news/mathematical-modelling-to-inform-next-generation-malaria-interventions
With increasing threats of malaria drug and insecticide resistance, there is now a need for novel malaria interventions to improve public health. According to the study published in Communications Medicine [...] inform decision-making around malaria interventions, integrating modelling evidence is equally as important. “Modeling evidence can guide and accelerate development of new malaria vaccines, monoclonal antibodies [...] medical interventions for malaria prevention, guided by reference...
