Antiprotozoal spirombandakamines A1 and A2, fused naphthylisoquinoline dimers from a Congolese <em>Ancistrocladus </em>plant (Publications)
methods with quantum-chemical ECD calculations. Their unique molecular frameworks may originate from "open-chain" dimers, such as 3, by an oxidation-induced cascade of reactions. They possess strong antiprotozoal
Total synthesis and biological investigation of (-)-artemisinin: the antimalarial activity of artemisinin is not stereospecific (Publications)
readily available S-(+)- and R-(-)-citronellene respectively. Subsequently, we have answered a still open question, i.e. specificity of artemisinins action. Using a drug sensitive Plasmodium falc. NF54 strain
Malaria Modelling Resource Centre (Page)
https://www.swisstph.ch/en/about/eph/disease-modelling/disease-modelling-and-intervention-dynamics/malaria-modelling-resource-centre
and to respond to specific requests for advice. The Resource Centre is built around the use of the OpenMalaria modelling platform. An introduction to the use of malaria models is presented as part of the
Total synthesis and biological investigation of (-)-artemisinin: the antimalarial activity of artemisinin is not stereospecific (Publications)
readily available S-(+)- and R-(-)-citronellene respectively. Subsequently, we have answered a still open question, i.e. specificity of artemisinins action. Using a drug sensitive Plasmodium falc. NF54 strain
Country modelling to support National Malaria Control Programs - High Burden to High Impact (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/country-modelling-to-support-national-malaria-control-programs-high-burden-to-high-impact
of malaria-related interventions. Our work is based on the OpenMalaria modelling platform developed by the Swiss TPH and collaborators. OpenMalaria has been developed as a decision-making support tool
Building-related health impacts in European and Chinese cities: a scalable assessment method (Publications)
impacts, both positive and negative, on public health. Our main objective was to develop a generic open impact model to estimate health impacts of emissions due to heat and power consumption of buildings [...] and large impacts on emissions. However, the life cycle impacts of different fuels is somewhat an open question. CONCLUSIONS: In conclusion, we were able to develop a practical model for city-level assessments
Characterization of the Ca2+-gated and voltage-dependent k+-channel slo-1 of nematodes and its interaction with emodepside (Publications)
in the absence of experimentally increased intracellular Ca2+, suggesting that emodepside directly opens C. elegans Slo-1a. Emodepside wash-out did not reverse the effect and the Slo-1 inhibitor verruculogen [...] properties among species. Most importantly, this study showed for the first time that emodepside directly opens a Slo-1 channel, significantly improving the understanding of the mode of action of this drug class
Measuring in-cabin school bus tailpipe and crankcase PM2.5: a new dual tracer method (Publications)
closed (1.4 and 12 microg/m3, respectively) as compared with open (0.44 and 1.3 microg/m3, respectively). For comparison, average closed- and open-window in-cabin total PM2.5 concentrations were 26 and 12
Country modelling to support National Malaria Control Programs - High Burden to High Impact (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/country-modelling-to-support-national-malaria-control-programs-high-burden-to-high-impact
of malaria-related interventions. Our work is based on the OpenMalaria modelling platform developed by the Swiss TPH and collaborators. OpenMalaria has been developed as a decision-making support tool
Characterization of the Ca2+-gated and voltage-dependent k+-channel slo-1 of nematodes and its interaction with emodepside (Publications)
in the absence of experimentally increased intracellular Ca2+, suggesting that emodepside directly opens C. elegans Slo-1a. Emodepside wash-out did not reverse the effect and the Slo-1 inhibitor verruculogen [...] properties among species. Most importantly, this study showed for the first time that emodepside directly opens a Slo-1 channel, significantly improving the understanding of the mode of action of this drug class
