Combining sociological, economic and epidemiological evidence to target malaria interventions in Papua New Guinea and beyond (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/combining-sociological-economic-and-epidemiological-evidence-to-target-malaria-interventions-in-papua-new-guinea-and-beyond
interventions. However, current recommendations focus exclusively on stratification by malaria risk. Yet, malaria is multi-factorial and the impact of interventions in a given setting also depends on [...] conceptual framework for a multi-dimensional malaria stratification beyond mere epidemiological indicators. Papua New Guinea (PNG) with its complex malaria epidemiology serves as a model country. Project [...] To improve the (cost-) effectiveness of malaria control and accelerate progress...
Environmental, Social, Economic and Health Impact Assessment (ESHIA) for a Field Study of a Self-Limiting Nondrive Strain of Genetically Modified... (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/environmental-social-economic-and-health-impact-assessment-eshia-for-a-field-study-of-a-self-limiting-nondrive-strain-of-genetically-modified-mosquitoes-on-behalf-of-target-malaria
Genetically modified mosquitoes (GMMs) represent great potential for malaria control in the future. Target Malaria – a vector control research alliance based at the Imperial College in London – aims to [...] develop genetic technologies to modify mosquitoes with the ultimate goal to reduce malaria transmission. Target Malaria uses a three-phased approach in this 170-million project funded by the Bill and Melinda
Modelling support to decision-making for malaria control in Benin (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/modelling-support-to-decision-making-for-malaria-control-in-benin
interact with the NMCP to gather a deeper understanding of the past malaria burden and control efforts. We then calibrate OpenMalaria , the malaria transmission simulation platform developed in-house, to quantify [...] National Malaria Control Program (NMCP) since 2018. The NMCP is currently updating its National Strategic Plan (NSP) for the period 2024-2026. This plan will guide the strategy and tools for malaria control [...] more impactful between administering seasonal malaria...
Deciphering Environmental Sensing in Malaria Parasites (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/deciphering-environmental-sensing-in-malaria-parasites
The Malaria Host Interactions Unit (MHIU) is studying the molecular interface between malaria parasites and their human host. Recent findings revealed the existence of intimate links between parasite [...] inducing specific transcriptional responses. This capability is surprising in light of the fact that malaria parasites have lost canonical nutrient sensing pathways present in other eukaryotic organisms. With
Experience capitalisation of Biovision’s environmental-friendly Malaria and African animal trypanosomiasis control projects from 2005-2020 for greater... (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/experience-capitalisation-of-biovisions-environmental-friendly-malaria-and-african-animal-trypanosomiasis-control-projects-from-2005-2020-for-greater-impact
be an assessment of Biovision’s engagement in Malaria and AAT control. Two major outputs shall be developed based on this review: a) an overview of Malaria and tsetse fly control activities supported through [...] of vector-borne human, animal and plant diseases. The current mandate focuses on programmes for Malaria and AAT control with a flagship character that had been implemented by Biovision and their strong [...] These will address the following four key topics: a) uptake, ownership and...
Core Malaria Modelling (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/core-malaria-modelling
and use of an individual-based model of malaria transmission dynamics known as OpenMalaria. This model is an open-source tool for simulating the dynamics of malaria transmission and epidemiology, and the [...] and economic outcomes. The opensource code and details of our model OpenMalaria can be found here . The model can simulate malaria in village or district size human populations, and has been used to address [...] TPH, our OpenMalaria model is used by a wide range of modellers worldwide....
Towards Elimination of Malaria in Tanzania (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/towards-elimination-of-malaria-in-tanzania
Malaria and poverty entertain a close relationship through historical times. Past studies have abundantly documented the benefits of malaria control on economic development and human well-being, and as [...] of malaria across the country declined, the heterogeneity in transmission greatly increased. At present, some areas in Tanzania remain with a very high transmission and hence with a high malaria burden [...] and risk stratification followed by decentralized malaria control planning has...
Country modelling to support National Malaria Control Programs - High Burden to High Impact (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/country-modelling-to-support-national-malaria-control-programs-high-burden-to-high-impact
the Roll Back Malaria partnership (RBM), public health modelers have been invited by the Global Fund to Fight AIDS, Tuberculosis and Malaria (“the Global Fund”) to support the national malaria programs on [...] of their data basis, current/past malaria trends in the country, and a simulation of the impact of malaria-related interventions. Our work is based on the OpenMalaria modelling platform developed by the [...] elaboration of country malaria strategic plans and provide insight to the coming...
Estimation of malaria parasite reservoir coverage using reactive case detection and active community fever screening from census data with rapid... (Publications)
areas where malaria transmission has been suppressed by vector control interventions many malaria control and elimination programmes are actively seeking new interventions to further reduce malaria prevalence [...] prevalence, incidence and transmission. Malaria infection prevalence and incidence has been shown to cluster geographically, especially at lower transmission levels, and as such a reactive strategy is frequently [...] infections than random searches, but this effect appears to be...
Clinical and laboratory predictors of death in African children with features of severe malaria: a systematic review and meta-analysis (Publications)
criteria for defining severe malaria have evolved over the last 20 years. We aimed to assess the strength of association of death with features currently characterizing severe malaria through a systematic review [...] Web of Knowledge) were searched to identify publications including African children with severe malaria. PRISMA guidelines were followed. Selection was based on design (epidemiological, clinical and treatment [...] treatment studies), setting (Africa), participants (children < 15...
