Hit-to-lead optimization of a novel class of potent, broad-spectrum trypanosomacides (Publications)
The parasitic trypanosomes Trypanosoma brucei and T. cruzi are responsible for significant human suffering in the form of human African trypanosomiasis (HAT) and Chagas disease. Drugs currently availa
Using the COMMVAC taxonomy to map vaccination communication interventions in Mozambique (Publications)
BACKGROUND: Improved communication about childhood vaccination is fundamental to increasing vaccine uptake in low-income countries. Mozambique, with 64% of children fully vaccinated, uses a range of c
Healthy lifestyle and heart rate variability in young adults (Publications)
BACKGROUND: We aimed to determine the association of a comprehensive healthy lifestyle with heart rate variability (HRV), a validated measure of autonomic function. DESIGN: This was a prospective coho
Transient hyperglycemia in patients with tuberculosis in Tanzania: implications for diabetes screening algorithms (Publications)
BACKGROUND: Diabetes mellitus (DM) increases tuberculosis (TB) risk while TB, as an infectious disease, leads to hyperglycemia. We compared hyperglycemia screening strategies in controls and TB patien
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation (Publications)
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1
40 years of progress in female cancer death risk: a Bayesian spatio-temporal mapping analysis in Switzerland (Publications)
BACKGROUND: In the past decades, mortality of female gender related cancers declined in Switzerland and other developed countries. Differences in the decrease and in spatial patterns within Switzerlan
Association between tuberculosis, diabetes and 25 hydroxyvitamin D in Tanzania: a longitudinal case control study (Publications)
BACKGROUND: Vitamin D level is inversely associated with tuberculosis (TB) and diabetes (DM). Vitamin D could be a mediator in the association between TB and DM. We examined the associations between v
Disease, activity and schoolchildren's health (DASH) in Port Elizabeth, South Africa: a study protocol (Publications)
BACKGROUND: An in-depth epidemiological investigation on intestinal parasite infections in an impoverished area of Port Elizabeth, South Africa provides a unique opportunity for research on its impact
Menopause is associated with accelerated lung function decline (Publications)
RATIONALE: Menopause is associated with changes in sex hormones, which affect immunity, inflammation, and osteoporosis and may impair lung function. Lung function decline has not previously been inves
