Promising Genotyping Technique for Assessing Antimalarial Drug Efficacy (News)
https://www.swisstph.ch/en/news/news-detail/news/promising-genotyping-technique-for-assessing-antimalarial-drug-efficacy
significant progress made in malaria control over the last twenty years. To ensure the continued effectiveness of antimalarial drugs, it is important to determine whether the malaria parasites in a patient's [...] Malaria remains a major global health concern, with 249 million cases and 608,000 deaths reported in 2022. Artemisinin-based combination therapies (ACTs) are currently one of the main strategies in the [...] patient's blood after malaria treatment are the same or different from those...
High levels of genetic diversity of <em>Plasmodium falciparum</em> populations in Papua New Guinea despite variable infection prevalence (Publications)
obstacle to malaria control. Here, we investigate the relationship between local variation in malaria epidemiology and parasite genetic diversity in Papua New Guinea (PNG). Cross-sectional malaria surveys [...] surveys were performed in 14 villages spanning four distinct malaria-endemic areas on the north coast, including one area that was sampled during the dry season. High-resolution msp2 genotyping of 2,147 blood
Aktueller Malariaschutz bei Kurzzeitaufenthalt (Publications)
average of 800 malaria cases are recorded annually in Germany. One person in a hundred dies of the disease. Travel advice given by experienced physicians is essential to raise awareness of malaria risk in endemic [...] endemic areas. Rational mosquito protection on skin and textiles reduces the risk of malaria and other arthropod-transmitted diseases (e. g. dengue fever). Regular intake of an antimalarial drugs to suppress [...] doctor after taking the SET as quickly as possible. These elements...
High levels of genetic diversity of <em>Plasmodium falciparum</em> populations in Papua New Guinea despite variable infection prevalence (Publications)
obstacle to malaria control. Here, we investigate the relationship between local variation in malaria epidemiology and parasite genetic diversity in Papua New Guinea (PNG). Cross-sectional malaria surveys [...] surveys were performed in 14 villages spanning four distinct malaria-endemic areas on the north coast, including one area that was sampled during the dry season. High-resolution msp2 genotyping of 2,147 blood
Aktueller Malariaschutz bei Kurzzeitaufenthalt (Publications)
average of 800 malaria cases are recorded annually in Germany. One person in a hundred dies of the disease. Travel advice given by experienced physicians is essential to raise awareness of malaria risk in endemic [...] endemic areas. Rational mosquito protection on skin and textiles reduces the risk of malaria and other arthropod-transmitted diseases (e. g. dengue fever). Regular intake of an antimalarial drugs to suppress [...] doctor after taking the SET as quickly as possible. These elements...
Nicolas Brancucci Appointed Professor at the University of Basel (News)
https://www.swisstph.ch/en/news/news-detail/news/nicolas-brancucci-appointed-professor-at-the-university-of-basel
on the process of malaria transmission stage formation. Brancucci will lead a new unit at Swiss TPH called "Malaria Host Interactions". The unit studies the way in which the malaria parasite P. falciparum [...] Basel, where he investigated epigenetic mechanisms controlling antigenic variation of the human malaria parasite Plasmodium falciparum . He then worked as a postdoctoral fellow in Boston (Harvard T. H
Bite Interruption Towards Elimination (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/bite-interruption-towards-elimination
progress in reducing malaria transmission in the Greater Mekong Subregion (GMS). However progress has stalled with reports of increase in the number of cases, multi-drug resistant malaria and pyrethroid-resistant [...] mobile and migrant populations, including forest-goers and forest rangers. Many of the dominant malaria vectors in the region feed and rest outdoors yet there is limited available protection against mosquito [...] populations. To address these pressing challenges, the University...
Antimalarial Drug Screening (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/antimalarial-drug-screening
performed by Medicines for Malaria Venture in 2009 and showed that OZ439 is well tolerated at all dose levels. So called 'proof of concept' phase II clinical trials with malaria patients showed that the [...] Our mandate with Medicines for Malaria Venture in Geneva comprises exploratory work on novel compounds from various sources. The goal is to identify novel chemical entities showing antimalarial activity [...] during the last decade is that such novel compounds can ultimately become part of...
Molecular assays for antimalarial drug resistance surveillance: a target product profile (Publications)
Antimalarial drug resistance is a major constraint for malaria control and elimination efforts. Artemisinin-based combination therapy is now the mainstay for malaria treatment. However, delayed parasite clearance [...] in the Greater Mekong Sub region and may emerge or spread to other malaria endemic regions. This spread is of great concern for malaria control programmes, as no alternatives to artemisinin-based combination [...] techniques can be standardised, and identify the requirements for...
Defining the next generation of <em>Plasmodium vivax</em> diagnostic tests for control and elimination: target product profiles (Publications)
prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control i [...] interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This species places dormant forms in human liver that cause repeated clinical [...] clinical attacks without involving another mosquito bite. The diagnosis...
