The N-terminal domain of <em>Plasmodium falciparum</em> circumsporozoite protein represents a target of protective immunity (Publications)
serum samples from people living in malaria-endemic regions. Importantly, recognition of the short N-terminal peptide (PfCS(65-110)) by sera from children living in a malaria-endemic region was associated with [...] N-terminal domain of the circumsporozoite protein (CSP) has been largely neglected in the search for a malaria vaccine in spite of being a target of inhibitory antibodies and protective T cell responses in mice [...] from disease. Taken together, these results underline the...
Disruption of erythrocyte rosettes and agglutination of erythrocytes infected with<em> Plasmodium falciparum</em> by the sera of Papua New Guineans (Publications)
Antibodies disrupting erythrocyte rosettes have been associated with protection against cerebral malaria, and antibodies agglutinating infected erythrocytes with reduced episodes of clinical disease. We [...] have studied the capacity of serum from Papua New Guinean adults and children with a spectrum of malaria exposure, including children and adults at the time of clinical disease, to disrupt erythrocyte rosettes [...] Rosette disrupting antibodies were equally frequent in children with...
The N-terminal domain of <em>Plasmodium falciparum</em> circumsporozoite protein represents a target of protective immunity (Publications)
serum samples from people living in malaria-endemic regions. Importantly, recognition of the short N-terminal peptide (PfCS(65-110)) by sera from children living in a malaria-endemic region was associated with [...] N-terminal domain of the circumsporozoite protein (CSP) has been largely neglected in the search for a malaria vaccine in spite of being a target of inhibitory antibodies and protective T cell responses in mice [...] from disease. Taken together, these results underline the...
Antimalarial efficacy of MMV390048, an inhibitor of <em>Plasmodium</em> phosphatidylinositol 4-kinase (Publications)
of MMV390048 to block all life cycle stages of the malaria parasite suggests that this compound should be further developed and may contribute to malaria control and eradication as part of a single-dose [...] As part of the global effort toward malaria eradication, phenotypic whole-cell screening revealed the 2-aminopyridine class of small molecules as a good starting point to develop new antimalarial drugs [...] we found that the derivative, MMV390048, lacked cross-resistance with current drugs...
Cost effectiveness of seasonal intermittent preventive treatment using amodiaquine & artesunate or sulphadoxine-pyrimethamine in Ghanaian children (Publications)
drug regimen at US$67.77 (61.71-74.75, CI 95%) per malaria case averted based on intervention costs only, US$64.93 (58.92-71.92, CI 95%) per malaria case averted once the provider cost savings are included [...] and AS & AQ bimonthly US$211.80 (127.05-399.14, CI 95%) per malaria case averted based on intervention costs only. The incidence of malaria in the post intervention period was higher in children who were [...] BACKGROUND: Intermittent preventive treatment for malaria in children (IPTc)...
Cost effectiveness of seasonal intermittent preventive treatment using amodiaquine & artesunate or sulphadoxine-pyrimethamine in Ghanaian children (Publications)
drug regimen at US$67.77 (61.71-74.75, CI 95%) per malaria case averted based on intervention costs only, US$64.93 (58.92-71.92, CI 95%) per malaria case averted once the provider cost savings are included [...] and AS & AQ bimonthly US$211.80 (127.05-399.14, CI 95%) per malaria case averted based on intervention costs only. The incidence of malaria in the post intervention period was higher in children who were [...] BACKGROUND: Intermittent preventive treatment for malaria in children (IPTc)...
Repellents and new "spaces of concern" in global health (Publications)
Today, malaria prevention hinges upon two domestic interventions: insecticide-treated bed nets and indoor residual spraying. As mosquitoes grow resistant to these tools, however, novel approaches to vector [...] vector control have become a priority area of malaria research and development. Spatial repellency, a volumetric mode of action that seeks to reduce disease transmission by creating an atmosphere inimical [...] of a non-insecticidal paradigm of vector control for how we understand the...
Repellents and new "spaces of concern" in global health (Publications)
Today, malaria prevention hinges upon two domestic interventions: insecticide-treated bed nets and indoor residual spraying. As mosquitoes grow resistant to these tools, however, novel approaches to vector [...] vector control have become a priority area of malaria research and development. Spatial repellency, a volumetric mode of action that seeks to reduce disease transmission by creating an atmosphere inimical [...] of a non-insecticidal paradigm of vector control for how we understand the...
MOSASWA Modelling Support (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/mosaswa-modelling-support
Indoor Residual Spraying (IRS) by Tchau Tchau Malaria (Goodbye Malaria, TTM) in Southern Mozambique as part of the MOSASWA (Mozambique, South Africa and Eswatini) initiative. The evaluation included three [...] The Global Fund to Fight AIDS, Tuberculosis and Malaria (The Global Fund) has commissioned Swiss TPH to evaluate the impact of the Lubombo Spatial Development Initiative 2 (LSDI2) implementation of Indoor [...] Group to create a connected model with data collated from the region that will...
The treatment of non-malarial febrile illness in Papua New Guinea: findings from cross sectional and longitudinal studies of health worker practice (Publications)
recently shifted from a presumptive to a 'test and treat' malaria case management policy. This shift was supported by the widespread introduction of malaria rapid diagnostic tests in health facilities across [...] detailing how to conduct and interpret a malaria rapid diagnostic test and how to treat test positive cases; however, little instruction on treating non-malaria febrile cases was provided. Accordingly, [...] l febrile patients in the 12-month period immediately following the...
