Situation épidémiologique avant la mise en eau du barrage hydroagricole de cinq villages de Bouaké, centre Côte d'Ivoire (Publications)
intermediate host snails of parasitic diseases related to water, and to assess the prevalence of malaria, schistosomiasis and soil-transmitted helminthiasis before dam construction. Mosquitoes were caught [...] in water bodies, and microscopic analyses of blood, stool and urine samples were carried out. Two malaria vector species were identified: Anopheles gambiae and Anopheles funestus. The average infective rate [...] species of were found: Plasmodium falciparum (predominant species),...
Identification and validation of a gene causing cross-resistance between insecticide classes in <em>Anopheles gambiae</em> from Ghana (Publications)
reductions in malaria incidence in sub-Saharan Africa. Sustaining these reductions will rely upon insecticides to control the mosquito malaria vectors. We report that in the primary African malaria vector, Anopheles [...] simultaneously reduces the efficacy of two of the four classes of insecticide routinely used for malaria control. The gene-expression profile of a highly DDT-resistant population of A. gambiae s.s. from
Resistance to Artemisinin Combination Therapies (ACTs): do not forget the partner drug! (Publications)
Artemisinin-based combination therapies (ACTs) have become the mainstay for malaria treatment in almost all malaria endemic settings. Artemisinin derivatives are highly potent and fast acting antimalarials; [...] regimen. When introduced, ACTs were highly efficacious and contributed to the steep decrease of malaria over the last decades. However, parasites with decreased susceptibility to artemisinins have emerged [...] ce and potential solutions to extend the useful therapeutic lifespan of the...
Mathematical modelling to examine disease, control measures, vaccine interactions and resistance to guide public health and disease elimination... (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/mathematical-modelling-to-examine-disease-control-measures-vaccine-interactions-and-resistance-to-guide-public-health-and-disease-elimination-strategies
resistance to disease interventions. We address two important pathogens: malaria and SARS-Cov-2. As we get closer to eliminating malaria and other diseases, preventing diseases from evolving resistance to response [...] detailed parasite models, mosquito-to-human transmission models and adapt individual-level models for malaria. We will also adapt models of SARS-CoV-2 to examine the emergence of vaccine-resistant COVID variants [...] pathogens. We will examine resistance to vaccines, drugs and...
Aetiology of fever in returning travelers and migrants: a systematic review and meta-analysis (Publications)
openia and hyperbilirubinemia were respectively 5-14, 3-11 and 5-7 times more likely in malaria than non-malaria patients. High variability of results between studies reflects heterogeneity in study design [...] investigations performed, and diseases included. CONCLUSION: Malaria accounted for one fifth of febrile cases, highlighting the importance of rapid malaria testing in febrile returning travelers, followed by other [...] met criteria for data extraction. Tropical infections accounted for...
Importance of factors determining the effective lifetime of a mass, long-lasting, insecticidal net distribution: a sensitivity analysis (Publications)
ensemble of 14 stochastic individual-based model variants for malaria in humans was used, combined with a deterministic model for malaria in mosquitoes. RESULTS: The effective lifetime was most sensitive [...] BACKGROUND: Long-lasting insecticidal nets (LLINs) reduce malaria transmission by protecting individuals from infectious bites, and by reducing mosquito survival. In recent years, millions of LLINs have [...] chemically and are destroyed, making repeated interventions necessary to prevent...
Aetiology of fever in returning travelers and migrants: a systematic review and meta-analysis (Publications)
openia and hyperbilirubinemia were respectively 5-14, 3-11 and 5-7 times more likely in malaria than non-malaria patients. High variability of results between studies reflects heterogeneity in study design [...] investigations performed, and diseases included. CONCLUSION: Malaria accounted for one fifth of febrile cases, highlighting the importance of rapid malaria testing in febrile returning travelers, followed by other [...] met criteria for data extraction. Tropical infections accounted for...
Importance of factors determining the effective lifetime of a mass, long-lasting, insecticidal net distribution: a sensitivity analysis (Publications)
ensemble of 14 stochastic individual-based model variants for malaria in humans was used, combined with a deterministic model for malaria in mosquitoes. RESULTS: The effective lifetime was most sensitive [...] BACKGROUND: Long-lasting insecticidal nets (LLINs) reduce malaria transmission by protecting individuals from infectious bites, and by reducing mosquito survival. In recent years, millions of LLINs have [...] chemically and are destroyed, making repeated interventions necessary to prevent...
Mathematical modelling to examine disease, control measures, vaccine interactions and resistance to guide public health and disease elimination... (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/mathematical-modelling-to-examine-disease-control-measures-vaccine-interactions-and-resistance-to-guide-public-health-and-disease-elimination-strategies
resistance to disease interventions. We address two important pathogens: malaria and SARS-Cov-2. As we get closer to eliminating malaria and other diseases, preventing diseases from evolving resistance to response [...] detailed parasite models, mosquito-to-human transmission models and adapt individual-level models for malaria. We will also adapt models of SARS-CoV-2 to examine the emergence of vaccine-resistant COVID variants [...] pathogens. We will examine resistance to vaccines, drugs and...
An assay to probe <em>Plasmodium falciparum</em> growth, transmission stage formation and early gametocyte development (Publications)
proliferation to sexual differentiation initiates the production of the gametocyte, which is the malaria parasite stage required for human-to-mosquito transmission. This protocol describes an assay designed [...] s on asexual replication, sexual conversion and early gametocyte development in the major human malaria parasite Plasmodium falciparum. Synchronized asexually replicating parasites are induced for gametocyte [...] transmission-blocking compounds and to further investigate the mechanism...
