The impact of using primaquine without prior G6PD testing: a case series describing the obstacles to the medical management of haemolysis (Publications)
vivax malaria in glucose-6-phosphate dehydrogenase (G6PD) deficient individuals employs weekly primaquine dosing. This is the only recommended regimen for this patient sub-group. If national malaria programs [...] with unknown G6PD status from two different countries were prescribed primaquine as per national malaria program guidelines. During treatment both patients presented to the clinic with symptoms of anaemia
Pan-Africa Network for Genomic Surveillance of Poverty Related Diseases and Emerging Pathogens (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/pan-africa-network-for-genomic-surveillance-of-poverty-related-diseases-and-emerging-pathogens
The main objective of the PANGenS project is to use genomic epidemiology of tuberculosis, malaria and emerging and re-emerging pathogens in Africa to better understand disease etiology, dynamics of disease [...] will aid infectious disease monitoring, and genomic surveillance will detect drug-resistant TB and malaria parasites. To achieve this, PANGenS will develop genomic epidemiology capacity across Africa by [...] components, from wet lab to bioinformatics, and to establish proof-of-concept...
Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across... (Publications)
blood life-cycle stage of the human malaria parasite Plasmodium falciparum. Several compounds displayed high in vivo efficacy in two different mouse models for malaria, P. berghei-infected mice and P. f
Cryptic population structure and insecticide resistance in <em>Anopheles gambiae</em> from the southern Democratic Republic of Congo (Publications)
Congo (DRC) suffers from one of the highest malaria burdens worldwide, but information on its Anopheles vector populations is relatively limited. Preventative malaria control in DRC is reliant on pyrethroid-treated
Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across... (Publications)
blood life-cycle stage of the human malaria parasite Plasmodium falciparum. Several compounds displayed high in vivo efficacy in two different mouse models for malaria, P. berghei-infected mice and P. f
Molecular Immunology | Research at Swiss TPH (Page)
https://www.swisstph.ch/en/about/med/molecular-immunology
vaccine development. Malaria P. falciparum: Developing a Synthetic Subunit Candidate Vaccine Malaria is one of the most serious infectious diseases of humans. New approaches to combat malaria are urgently needed [...] efficacy of therapeutic interventions. This research focuses primarily on three infectious diseases: malaria due to Plasmodium falciparum, bacterial meningitis caused by Neisseria meningitides and Streptococcus [...] developing synthetic peptide structures that induce...
New Vector Control Interventions (Page)
https://www.swisstph.ch/en/about/eph/vector-biology/new-vector-control-interventions
al. A review of selective indoor residual spraying for malaria control. Malar J . 2024;23:252. DOI: 10.1186/s12936-024-05053-3 Related Topics Malaria Urban Health Related Activities Clinical Trials Preclinical [...] Access (ViALLIN MUsAcc) Long-lasting insecticidal nets (LLINs), or bed nets, are the mainstay of malaria control. However, more than 50% of people living in endemic areas are currently unprotected because [...] expected lifespan. The aim of this project is to develop a digital tool...
Drug Discovery Work (Page)
https://www.swisstph.ch/en/about/mpi/parasite-chemotherapy/drug-discovery-work
evaluation of new compounds. The Medicines for Malaria Venture (MMV) Foundation supports the project ‘Syntheticperoxides’ and the new projects ‘Oral diamidines for malaria’. With a master contract with the MMV [...] Drug Discovery Work Tropical parasitic diseases, as malaria, African sleeping sickness, Chagas disease or Leishmaniasis represent still a large health risk for a majority of the worlds population. These [...] trematodes. Links WHO/TDR European COST B22 Drugs for Neglected Diseases...
Modelling the impact of insecticide-based control interventions on the evolution of insecticide resistance and disease transmission (Publications)
threshold level of mosquitoes below which transmission of malaria is interrupted. It is based on a classic Ross-Macdonald derivation of the malaria basic reproductive number (R0) and may be used to assess [...] (iv) the impact of resistance once it has arisen and, in particular, whether it is sufficient for malaria transmission to resume. The model consists of a system of difference equations that tracks the immature [...] and easily generalizable to many scenarios using different calibrations...
Emergence of FY*A(null) in a <em>Plasmodium vivax</em>-endemic region of Papua New Guinea (Publications)
Human genetic polymorphisms of this nature are common in malarious regions, and all four human malaria parasites are holoendemic below 1500 meters in PNG. At this elevation, a prominent condition cha [...] demonstrated that alpha(+)-thalassemia is associated with increased susceptibility to uncomplicated malaria among young children. It is further proposed that alpha(+)-thalassemia may facilitate so- called [...] vivax infection to act later in life as a "natural vaccine" against severe...
