Leptospira seroprevalence and risk factors in health centre patients in Hoima District, Western Uganda (Publications)
consented participants. Overall, 69% reported having fever in the past year, with 49% reporting malaria, 14% malaria relapse, 6% typhoid fever, 3% brucellosis, and 0% leptospirosis. We tested sera by microscopic [...] Nigeria (serogroup Pyrogenes). Probable recent leptospirosis was associated with having self-reported malaria within the past year (p = 0.048). Higher risk activities included skinning cattle (n = 6) with 12 [...] serogroup). Leptospirosis should be a diagnostic consideration in...
Promising Antimalarial Drug Proves Ineffective at Saving Children’s Lives (News)
https://www.swisstph.ch/en/news/news-detail/news/promising-antimalarial-drug-proves-ineffective-at-saving-childrens-lives
continue to die from malaria, and promising interventions such as RAS will fail to meet their full potential.” About the study The Community Access to Rectal Artesunate for Malaria (CARAMAL) project was [...] antimalarial drug, proves ineffective at saving the lives of young children suffering from severe malaria, according to the results of a new study conducted by the Swiss Tropical and Public Health Institute [...] under real-world conditions, RAS did not improve the odds of survival for...
Disease Modelling and Intervention Dynamics | Swiss TPH (Page)
https://www.swisstph.ch/en/about/eph/disease-modelling/disease-modelling-and-intervention-dynamics
penny@unibas.ch Links Malaria Modelling Resource Centre Key Projects Shaping Next-Generation Interventions for Malaria Prevention Despite progress to reduce malaria burden, malaria parasites are becoming [...] Selected Projects All Projects Mathematical models to define new malaria immunotherapies and interventions to meet public health needs Core Malaria Modelling Mathematical modelling to examine disease, control [...] to address contemporary issues in infectious diseases and global health. We...
Antiparasitic agents: new drugs on the horizon (Publications)
the currently available medicines. Public-private partnerships aiming to develop new medicines for malaria and sleeping sickness have, over the past 12 years, brought forward several drug candidates that [...] compounds against trypanosomes and other parasites. Thus, finally, new therapeutic agents against malaria and sleeping sickness are within reach
Antiparasitic agents: new drugs on the horizon (Publications)
the currently available medicines. Public-private partnerships aiming to develop new medicines for malaria and sleeping sickness have, over the past 12 years, brought forward several drug candidates that [...] compounds against trypanosomes and other parasites. Thus, finally, new therapeutic agents against malaria and sleeping sickness are within reach
KALUMI - A Phase 2 Study on KAF156-Lumefantrine-SDF for acute uncomplicated Plasmodium falciparum in children (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/kalumi-a-phase-2-study-on-kaf156-lumefantrine-sdf-for-acute-uncomplicated-plasmodium-falciparum-in-children
KAF156 and Lumefantrine-SDF combination in the treatment of acute uncomplicated Plasmodium falciparum Malaria. This study aims to confirm the efficacy, safety and tolerability of KLU156, a fixed dose combination [...] and children ≥ 5 kg body weight and ≥ 2 months of age suffering from uncomplicated P. falciparum malaria (with or without other Plasmodium spp. co-infection).
Antimalarial lead-optimization studies on a 2,6-imidazopyridine series within a constrained chemical space to circumvent atypical dose-response curves... (Publications)
falciparum NODscidIL2Rgammanull mouse malaria infection model. The observation of atypical dose-response curves when some compounds were tested against multidrug resistant malaria parasite strains guided the o
Uses of mosquito-stage transmission-blocking vaccines against <em>Plasmodium falciparum</em> (Publications)
stage or mosquito stage transmission blocking vaccines (TBVs) against malaria. The combination of TBVs with biocides or other malaria vaccines will increase chances of interrupting transmission, whereas
Quality control of long-lasting insecticidal nets: are we neglecting it? (Publications)
long-lasting insecticidal nets (LLINs) for malaria control have been delivered to recipient countries. LLINs are the largest single item in the global malaria control budget. To be eligible for donor-funded
Uses of mosquito-stage transmission-blocking vaccines against <em>Plasmodium falciparum</em> (Publications)
stage or mosquito stage transmission blocking vaccines (TBVs) against malaria. The combination of TBVs with biocides or other malaria vaccines will increase chances of interrupting transmission, whereas
