Urban agriculture and <em>Anopheles</em> habitats in Dar es Salaam, Tanzania (Publications)
than a fifth of all breeding sites of malaria vectors in Dar es Salaam. It is suggested that strategies comprising an integrated malaria control effort in malaria-endemic African cities include participatory
Comparative study of the effects of artemether and artesunate on juvenile and adult<em> Schistosoma mansoni</em> in experimentally infected mice (Publications)
stages of schistosome parasites. Since artemisinin derivatives will be increasingly used to treat malaria, it is important to study the effects of 7-day monotherapy regimens on schistosome infections. We [...] artemether or artesunate at various doses and regimens including those currently used for monotherapy of malaria. Three doses of artemether, at concentrations of 150 or 300 mg/kg, administered to mice with juvenile [...] discussions on the effect and use of artemisinin derivatives against...
The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue (Publications)
cavity of the enzyme. Like MB, also PYO was also found to be active against blood schizonts of the malaria parasite P. falciparum in vitro. Furthermore, both compounds were active against the disease transmitting [...] PYO, is well tolerated and represents a promising agent for MB-based combination therapies against malaria. Current and future clinical studies can be guided by the comparisons between MB and PYO reported [...] reported here. Additionally, it is of interest to study if and to what...
Identification of new PNEPs indicates a substantial non-PEXEL exportome and underpins common features in<em> Plasmodium falciparum</em> protein export (Publications)
Malaria blood stage parasites export a large number of proteins into their host erythrocyte to change it from a container of predominantly hemoglobin optimized for the transport of oxygen into a niche [...] how many further PNEPs exist. Here we report the identification of new PNEPs in the most virulent malaria parasite Plasmodium falciparum. This includes proteins with a domain structure deviating from previously [...] highlighting protein translocation in the parasite periphery as a general...
Spatial distribution of the chromosomal forms of <em>anopheles gambiae</em> in Mali (Publications)
BACKGROUND: Maps of the distribution of malaria vectors are useful tools for stratification of malaria risk and for selective vector control strategies. Although the distribution of members of the Anopheles [...] (insecticide resistance management) and may serve as a decision support tool for the basis for future malaria control strategies including genetically manipulated mosquitoes
<em>Plasmodium vivax</em> antigen discovery based on alpha-helical coiled coil protein motif (Publications)
partial or high alpha-helical content. Antigenicity was evaluated using human sera samples from malaria-endemic areas of Colombia and Papua New Guinea. Eight of these fragments were selected and used to [...] BALB/c mice. ELISA assays indicated strong reactivity of serum samples from individuals residing in malaria-endemic regions and sera of immunized mice, with the alpha-helical coiled coil structures. In addition [...] whole parasites. Results here point to the alpha-helical coiled coil...
Spatial effects of mosquito bednets on child mortality (Publications)
Insecticide treated nets (ITN) have been proven to be an effective tool in reducing the burden of malaria. Few randomized clinical trials examined the spatial effect of ITNs on child mortality at a high [...] coverage. We analyzed for the first time data from a large follow-up study in an area of high perennial malaria transmission in southern Tanzania to describe the spatial effects of bednets on all-cause child mortality [...] with insecticide, and (2) the relative homogeneity of coverage with...
The mode of action of spatial repellents and their impact on vectorial capacity of<em> Anopheles gambiae sensu stricto</em> (Publications)
Malaria vector control relies on toxicity of insecticides used in long lasting insecticide treated nets and indoor residual spraying. This is despite evidence that sub-lethal insecticides reduce human-vector [...] human-vector contact and malaria transmission. The impact of sub-lethal insecticides on host seeking and blood feeding of mosquitoes was measured. Taxis boxes distinguished between repellency and attraction [...] target product profiles of spatial repellent products that can be used to...
Strong off-target antibody reactivity to malarial antigens induced by RTS,S/AS01E vaccination is associated with protection (Publications)
lower clinical malaria incidence after adjusting for age group, site and post-vaccination anti-CSP levels. RTS,S/AS01E-induced IgG may bind strongly not only to CSP, but to unrelated malaria antigens, and [...] and this seems to either confer, or at least be a marker of, increased protection from clinical malaria.
Semi-field evaluation of a volatile transfluthrin-based intervention reveals efficacy as a spatial repellent and evidence of other modes of action (Publications)
Presently, the most common malaria control tools-i.e., long lasting insecticide-treated nets (LLINs) and indoor residual spraying (IRS)-are limited to targeting indoor biting and resting behaviors of Anopheles [...] Anopheles mosquito species. Few interventions are targeted towards malaria control in areas where transmission is driven or persists due to outdoor biting behaviors. This study investigated a volatile [...] Southern Province, Zambia, is one such environment where outdoor biting is...
