<em>Plasmodium falciparum</em> merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic... (Publications)
allelic families of Plasmodium falciparum merozoite surface proteins 2 are considered promising malaria vaccine candidates. The aim of the current study is to characterize the immune response (epitope [...] (epitope mapping) in naturally exposed individuals and relate immune responses to the risk of clinical malaria. METHODS: To optimize their construction, the fine specificity of human serum antibodies from donors [...] response to individual epitopes within the 3D7 family-specific region...
Clonal expansion of artemisinin-resistant <em>Plasmodium falciparum</em> in Uganda is associated with substandard treatment practices (Publications)
the frame of the Community Access to Rectal Artesunate for Malaria project, blood samples were collected from children with signs of severe malaria before and after RAS implementation. K13 polymorphisms were [...] a driver of this recent emergence. Rectal artesunate (RAS) as pre-referral treatment for severe malaria in children was implemented in 2019 in Northern Uganda. The objective of this study was to determine
Evaluation of anopheline diversity and abundance across outdoor collection schemes utilizing cdc light traps in Nchelenge District, Zambia (Publications)
In the global fight against malaria, standard vector control methods such as indoor residual spraying (IRS) and insecticide-treated nets (ITNs) are intended to protect inside residential structures and [...] may be exposed to outdoors. Nchelenge District in northern Zambia experiences persistently high malaria transmission even with ITNs and IRS in place. However, very few studies have examined outdoor vector [...] including a number of infectious An. funestus, may partially explain the...
Population pharmacokinetics of the antimalarial amodiaquine: a pooled analysis to optimize dosing (Publications)
Amodiaquine plus artesunate is the recommended antimalarial treatment in many malaria-endemic countries. However, pediatric doses are largely based on a linear extrapolation from adult doses. We pooled [...] amodiaquine, to optimize the dose across all age groups. Adults and children with uncomplicated malaria received daily weight-based doses of amodiaquine or artesunate-amodiaquine over three days. Plasma [...] 22.4% (15.6 - 31.9%) lower at the start of treatment than during convalescence,...
High proportions of asymptomatic and submicroscopic <em>Plasmodium vivax </em>infections in a peri-urban area of low transmission in the Brazilian... (Publications)
regional elimination, it is important to investigate the role of this asymptomatic reservoir in malaria transmission in peri-urban areas. This study aimed to estimate the prevalence of Plasmodium spp. [...] conducted including all inhabitants in a peri-urban area of Manaus, western Amazonas State, Brazil. Malaria parasites were detected by light microscopy (LM) and qPCR. Sexual stages of Plasmodium spp. were [...] carried gametocytes and presented low asexual parasitemia. This reservoir actively...
Further development of simulations of Plasmodium falciparum interventions and their integration with the needs of stakeholders (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/further-development-of-simulations-of-plasmodium-falciparum-interventions-and-their-integration-with-the-needs-of-stakeholders
platform for comparing, fitting, and evaluating different individual-based stochastic simulations of malaria epidemiology. Aims In the next phase of the project, we propose to exploit the functionality of this [...] potential clients, and develop capacity to anticipate and react promptly to requests from the R & D and malaria intervention communities.
Infection Biology and Molecular Epidemiology | Swiss TPH (Page)
https://www.swisstph.ch/en/infection-biology-and-molecular-epidemiology
infectious diseases. In the field of the life sciences, Swiss TPH places particular emphasis on malaria, tuberculosis and other poverty-related infectious diseases. We utilise state-of-the-art basic research [...] of new drugs, diagnostics and vaccines. Helminths HIV/AIDS Human African Trypanosomiasis (HAT) Malaria Neglected Tropical Diseases (NTDs) Tuberculosis
dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors (Publications)
route for therapeutic intervention against malaria. Here we report inhibition and structural studies on the deoxyuridine nucleotidohydrolase from the malaria parasite Plasmodium falciparum (PfdUTPase)
Delayed anemia after treatment with injectable artesunate in the democratic republic of the Congo: a manageable issue (Publications)
treatment of severe malaria. A total of 350 patients (215 [61.4%] < 5 years of age and 135 [38.6%] > /= 5 years of age) were followed-up after treatment with injectable artesunate for severe malaria in hospitals
The epidemiology of multiple <em>Plasmodium falciparum</em> infections. 7. Dynamics of multiple <em>Plasmodium falciparum </em>infections in infants... (Publications)
The force of infection and recovery rate for malaria in infants in a highly endemic area of Tanzania were analysed using polymerase chain reaction-restriction fragment length polymorphism genotyping of [...] recovery rates were in children under 4 months of age. The higher susceptibility of infants to clinical malaria in comparison with older children, in areas of very high transmission, may be largely a consequence
