Combining synthetic human odours and low-cost electrocuting grids to attract and kill outdoor-biting mosquitoes: field and semi-field evaluation of an... (Publications)
BACKGROUND: On-going malaria transmission is increasingly mediated by outdoor-biting vectors, especially where indoor insecticidal interventions such as long-lasting insecticide treated nets (LLINs) are [...] dusk and dawn. MLBs fitted with one, two or three electrocuting grids were compared outdoors in a malaria endemic village in Tanzania, where vectors had lost susceptibility to pyrethroids. MLBs with three
Proteomic analysis of exported chaperone/co-chaperone complexes of <em>P. falciparum</em> reveals an array of complex protein-protein interactions (Publications)
Malaria parasites modify their human host cell, the mature erythrocyte. This modification is mediated by a large number of parasite proteins that are exported to the host cell, and is also the underlying [...] underlying cause for the pathology caused by malaria infection. Amongst these proteins are many Hsp40 co-chaperones, and a single Hsp70. These proteins have been implicated in several processes in the host cell
Pascal Mäser Appointed Full Professor at the University of Basel (News)
https://www.swisstph.ch/en/news/news-detail/news/pascal-maeser-appointed-full-professor-at-the-university-of-basel
(MPI) at Swiss TPH. Mäser’s research focuses on drug discovery for trypanosomatid parasites and malaria, modes of drug action and mechanisms of drug resistance. His unit entails a drug discovery platform [...] new drug candidates, including fexinidazole for human African trypanosomiasis and artefenomel for malaria. Since 2014, Mäser has been an Associate Professor of Infection Biology at the University of Basel
Molecular methods for tracking residual <em>Plasmodium falciparum </em>transmission in a close-to-elimination setting in Zanzibar (Publications)
essential for surveillance studies conducted to inform malaria control strategies in close-to-elimination settings. Molecular monitoring of residual malaria infections usually requires a large study size, therefore [...] screening large sample sets represents primarily a research tool that should inform the design of malaria elimination strategies. It may also prove beneficial for diagnostic tasks in surveillance-response
Determinants of bed net use conditional on access in population surveys in Ghana (Publications)
e-treated nets (ITNs) are one of the most effective and widely available methods for preventing malaria, and there is interest in understanding the complexities of behavioural drivers of non-use among [...] access to a net. METHODS: Survey data from the Ghana 2014 Demographic and Health Survey and the 2016 Malaria Indicator Survey were used to calculate household members' access to space under a net as well as [...] households when compared to the poorest category. In 2014, exposure to messages...
Long-term acceptability, durability and bio-efficacy of ZeroVector® durable lining for vector control in Papua New Guinea (Publications)
had previously been installed in 40 homes across four study sites representing a cross section of malaria transmission risk and housing style. Structured questionnaires, DL visual inspections and group [...] at 36-months post-installation, the material and fixtures proved durable and the efficacy against malaria vectors did not decrease. However, the DL material had been removed from over 50% of the original [...] suggest DL may not be an appropriate vector control method for large-scale use in...
Co-infection of the four major <em>Plasmodium </em>species: effects on densities and gametocyte carriage (Publications)
BACKGROUND: Co-infection of the four major species of human malaria parasite Plasmodium falciparum (Pf), P. vivax (Pv), P. malariae (Pm), and P. ovale sp. (Po) is regularly observed, but there is limited [...] (95% CI: 0.95, 1.79) for gametocytes. This excess co-infection risk was partially attributable to malaria infections clustering in some villages. Pf-Pv-Pm triple infections were four times more frequent
Resistance of <em>Anopheles stephensi</em> to selected insecticides used for indoor residual spraying and long-lasting insecticidal nets in Ethiopia (Publications)
BACKGROUND: Malaria, transmitted by the bite of infective female Anopheles mosquitoes, remains a global public health problem. The presence of invasive Anopheles stephensi, capable of transmitting Plasmodium [...] 2016. The ecology of this mosquito species differs from that of Anopheles arabiensis, the primary malaria vector in Ethiopia. This study aimed to evaluate the efficacy of selected insecticides, which are [...] are used in indoor residual spraying (IRS) and selected long-lasting...
Local concepts of anemia-related illnesses and public health implications in the Taabo health demographic surveillance system, Côte d'Ivoire (Publications)
newly recruited ones. Malaria und nutritional issues as understood and managed by the population differed from definitions and recommendations provided by the health system. Malaria was not acknowledged [...] which in turn might affect their health status. Local terminology and beliefs about anemia and malaria should be carefully considered when developing health intervention and education programs. The similarity
Long-term trends in <em>Anopheles gambiae</em> insecticide resistance in Côte d'Ivoire (Publications)
for ITNs. The rapid rise in insecticide resistance in African malaria vectors has raised alarms about the sustainability of existing malaria control activities. This problem might be particularly acute [...] BackgroundMalaria control is heavily dependent on the use of insecticides that target adult mosquito vectors via insecticide treated nets (ITNs) or indoor residual spraying (IRS). Four classes of insecticide
