Searched for malaria.

1. The development and evaluation of a self-marking unit to estimate malaria vector survival and dispersal distance (Publications)

   The development and evaluation of a self-marking unit to estimate malaria vector survival and dispersal distance

   Relevance:

   diseases such as malaria. Mosquito mark-release-recapture (MMRR) experiments are a popular method of measuring the survival and dispersal of disease vectors; however, examples with African malaria vectors are [...] This study demonstrates the successful use of a self-marking device in an MMRR study with African malaria vectors. This method may be useful in investigating population structure and dispersal of mosquitoes

2. Malaria: «Einstein» und die Spritze der Hoffnung (Publications)

   Malaria: «Einstein» und die Spritze der Hoffnung

   Relevance:

   In Afrika läuft die weltweit erste Impfkampagne gegen Malaria. In Ghana, Malawi und Kenia werden bis 2022 gegen zwei Millionen Kleinkinder mit dem Vakzin «RTS’S» geimpft. «Einstein» hat die Entwicklung [...] begleitet. Die Langzeit-Dokumentation zeigt auf, wie schwierig der Weg zur ersehnten neuen Waffe gegen Malaria war. Die Schweiz spielte bei der Entwicklung des Impfstoffs eine tragende Rolle, doch die Testreihen [...] und echte Forschungspartnerschaft zwischen Nord und Süd möglich war. Die...

3. Mapping routine malaria incidence at village level for targeted control in Papua New Guinea (Publications)

   Mapping routine malaria incidence at village level for targeted control in Papua New Guinea

   Relevance:

   Malaria surveillance and response-systems are essential for identifying the areas most affected by malaria and for targeting interventions and optimising resources. This study aimed to assess whether the

4. Safety and immunogenicity of the RTS,S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in... (Publications)

   Safety and immunogenicity of the RTS,S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in sub-Saharan Africa

   Relevance:

   BACKGROUND: We assessed the safety and immunogenicity of the RTS,S/AS01 malaria vaccine in a subset of children identified as HIV-infected during a large phase III randomized controlled trial conducted

5. Multiplicity of asymptomatic <em>Plasmodium falciparum </em>infections and risk of clinical malaria: a systematic review and pooled analysis of... (Publications)

   Multiplicity of asymptomatic <em>Plasmodium falciparum </em>infections and risk of clinical malaria: a systematic review and pooled analysis of individual participant data

   Relevance:

   subsequent febrile malaria or with an increased risk. CONCLUSIONS: The number of clones in asymptomatic P. falciparum infections is associated with different risks of subsequent clinical malaria depending on [...] BACKGROUND: The malaria parasite Plasmodium falciparum holds an extensive genetic polymorphism. In this pooled analysis, we investigate how the multiplicity, i.e. the number of co-infecting clones, in [...] in asymptomatic P. falciparum infections affects the subsequent risk of...

6. Sex: how malaria parasites get turned on (Publications)

   Sex: how malaria parasites get turned on

   Relevance:

   initiation of this cell fate decision, ultimately providing the malaria community with a novel and important tool in the battle to prevent malaria transmission.

7. Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria (Publications)

   Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria

   Relevance:

   Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on [...] Altogether, these findings provide a mechanistic link between EVs and vascular dysfunction during malaria infection.

8. Mapping and functional analysis of heterochromatin protein 1 phosphorylation in the malaria parasite <em>Plasmodium falciparum</em> (Publications)

   Mapping and functional analysis of heterochromatin protein 1 phosphorylation in the malaria parasite <em>Plasmodium falciparum</em>

   Relevance:

   protein 1 (HP1) is important for dynamically regulating its various functions. However, in the malaria parasite Plasmodium falciparum both the function of HP1 phosphorylation and the identity of the protein

9. Immunization of malaria pre-exposed volunteers with PfSPZ Vaccine elicits long-lived IgM invasion-inhibitory and complement-fixing antibodies (Publications)

   Immunization of malaria pre-exposed volunteers with PfSPZ Vaccine elicits long-lived IgM invasion-inhibitory and complement-fixing antibodies

   Relevance:

   antibodies are induced following immunization of malaria pre-exposed volunteers with PfSPZ Vaccine. We found that in addition to anti-PfCSP IgG, Malaria pre-exposed volunteers developed anti-PfCSP IgM [...] and Pf sporozoite-binding IgM antibodies are induced following immunization of PfSPZ Vaccine in malaria pre-exposed individuals and that IgM antibodies can inhibit Pf sporozoite invasion into hepatocytes

10. The effect of case management and vector-control interventions on space-time patterns of malaria incidence in Uganda (Publications)

    The effect of case management and vector-control interventions on space-time patterns of malaria incidence in Uganda

    Relevance:

    space-time patterns of malaria incidence in children < 5 are similar to those of parasitaemia risk predicted from the malaria indicator survey of 2014-15. CONCLUSION: The decline in malaria incidence highlights [...] METHODS: Bayesian spatio-temporal negative binomial models were fitted on district-aggregated monthly malaria cases, reported by two age groups, defined by a cut-off age of 5 years. The effects of interventions [...] trigonometric functions were incorporated in the models to take...