Imaging of <em>Plasmodium</em> liver stages to drive next-generation antimalarial drug discovery (Publications)
mg/kg) in rodent models of malaria and shows potent in vivo blood-stage therapeutic activity. The open source chemical tools resulting from our effort provide starting points for future drug discovery
Tolerability and efficacy of a pediatric granule formulation of artesunate-mefloquine in young children from Cameroon with uncomplicated falciparum... (Publications)
pediatric formulation of artesunate and mefloquine (Artequin Pediatric) has been developed. In this open, non-comparative study in Cameroonian children with uncomplicated falciparum malaria, the safety and
A randomised, controlled trial of once daily and multi-dose daily gentamicin in young Kenyan infants (Publications)
for use in young infants where routine therapeutic drug monitoring is not possible. METHODS: In an open, randomised, controlled trial, infants with suspected severe sepsis admitted to a Kenyan, rural district
Model-based integration of genomics and metabolomics reveals SNP functionality in <em>Mycobacterium tuberculosis</em> (Publications)
the antibiotic para-aminosalicylic acid. Our method is broadly applicable across microbial life, opening possibilities for the development of more selective treatment strategies.
Retention in care and virological failure among adult HIV+ patients on second-line ART in Rwanda: a national representative study (Publications)
METHODS: A two-stage cluster sampling design was undertaken. 49 of 340 health facilities linked to the open-source electronic medical record (EMR) system of Rwanda were randomly sampled. Data sampling criteria
Identification of an <em>Onchocerca volvulus</em> cDNA encoding a low-molecular-weight antigen uniquely recognized by onchocerciasis patient sera (Publications)
a lambda gt11 cDNA expression library derived from microfilariae-producing female O. volvulus. The open reading frame encodes 152 amino acids, and the deduced sequence predicts a Mr of 16,850 (consistent
Targeting <em>Plasmodium</em> PI(4)K to eliminate malaria (Publications)
ylinositol-4-phosphate. Collectively, our data define PI(4)K as a key Plasmodium vulnerability, opening up new avenues of target-based discovery to identify drugs with an ideal activity profile for the
A primaquine-chloroquine hybrid with dual activity against <em>Plasmodium</em> liver and blood stages (Publications)
Based on the optimized synthetic pathway, the compound is accessible in a smooth and versatile way and open for potential further molecular modification.
If I tweet will you cite later? Follow-up on the effect of social media exposure on article downloads and citations (Publications)
in terms of downloads (p = 0.72) and citations (p= 0.30) for all papers and when we stratified by open access status. CONCLUSIONS: Longer observation time did not increase the relative differences in the
Malaria, climate variability, and interventions: modelling transmission dynamics (Publications)
population. The model captures some of the main mechanisms of human, parasite, and vector dynamics, and opens the possibility to forecast malaria in endemic regions, taking into account the interaction between