Retention in care and virological failure among adult HIV+ patients on second-line ART in Rwanda: a national representative study (Publications)
METHODS: A two-stage cluster sampling design was undertaken. 49 of 340 health facilities linked to the open-source electronic medical record (EMR) system of Rwanda were randomly sampled. Data sampling criteria
Identification of an <em>Onchocerca volvulus</em> cDNA encoding a low-molecular-weight antigen uniquely recognized by onchocerciasis patient sera (Publications)
a lambda gt11 cDNA expression library derived from microfilariae-producing female O. volvulus. The open reading frame encodes 152 amino acids, and the deduced sequence predicts a Mr of 16,850 (consistent
Targeting <em>Plasmodium</em> PI(4)K to eliminate malaria (Publications)
ylinositol-4-phosphate. Collectively, our data define PI(4)K as a key Plasmodium vulnerability, opening up new avenues of target-based discovery to identify drugs with an ideal activity profile for the
A primaquine-chloroquine hybrid with dual activity against <em>Plasmodium</em> liver and blood stages (Publications)
Based on the optimized synthetic pathway, the compound is accessible in a smooth and versatile way and open for potential further molecular modification.
If I tweet will you cite later? Follow-up on the effect of social media exposure on article downloads and citations (Publications)
in terms of downloads (p = 0.72) and citations (p= 0.30) for all papers and when we stratified by open access status. CONCLUSIONS: Longer observation time did not increase the relative differences in the
Malaria, climate variability, and interventions: modelling transmission dynamics (Publications)
population. The model captures some of the main mechanisms of human, parasite, and vector dynamics, and opens the possibility to forecast malaria in endemic regions, taking into account the interaction between
Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation (Publications)
diffusible lipid secreted by the human pathogen Mycobacterium ulcerans, which induces the formation of open skin lesions referred to as Buruli ulcers. Here, we show that mycolactone operates by hijacking the
Synthesis and antiplasmodial activity of new N-[3-(4-{3-[(7-chloroquinolin-4-yl)amino]propyl}piperazin-1-yl)propyl]carboxamides (Publications)
-aminopropyl)piperazin-1-yl]propyl}-7-chloroquinolin-4-amine with polymer-bound carboxylic acids opened straightforward access to novel aminoquinolines with activity against Plasmodium falciparum strains
Identification of an <em>Onchocerca volvulus</em> cDNA encoding a low-molecular-weight antigen uniquely recognized by onchocerciasis patient sera (Publications)
a lambda gt11 cDNA expression library derived from microfilariae-producing female O. volvulus. The open reading frame encodes 152 amino acids, and the deduced sequence predicts a Mr of 16,850 (consistent
Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation (Publications)
diffusible lipid secreted by the human pathogen Mycobacterium ulcerans, which induces the formation of open skin lesions referred to as Buruli ulcers. Here, we show that mycolactone operates by hijacking the
