Identification of 2,4-disubstituted imidazopyridines as hemozoin formation inhibitors with fast-killing kinetics and <em>in vivo</em> efficacy in the... (Publications)
A series of 2,4-disubstituted imidazopyridines, originating from a SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falci
Pyridine-4(1<em>H</em>)-one alkaloids from <em>Waltheria indica</em> as antitrypanosomatid agents (Publications)
Twelve new pyridine-4(1H)-one derivatives, namely, 8-demethoxywaltherione F (1), waltheriones R-V (2, 6, 7, 10, and 11), 1-methoxywaltherione O (3), (S)-15-hydroxywaltherione G (4), (8R)-8-hydroxywalt
Cumulative occupational exposures and lung function decline in two large general population cohorts (Publications)
RATIONALE: Few longitudinal studies have assessed the relationship between occupational exposures and lung function decline in the general population, with sufficiently long follow-up. OBJECTIVES: Our
Potent and selective antiplasmodial activity of the cyanobacterial alkaloid nostocarboline and its dimers (Publications)
The quaternary beta-carbolinium alkaloid nostocarboline from the cyanobacterium Nostoc 78-12A and 10 bis-cationic dimeric derivatives were evaluated against four protozoan parasites and low micromolar
Antiprotozoal activities of new bis-chlorophenyl derivatives of bicyclic octanes and aza-nonanes (Publications)
The in vitro activity of newly synthesized bis-(chlorophenyl)-azabicyclo[3.2.2]nonanes and bis-(chlorophenyl)-bicyclo[2.2.2]octanes against Plasmodium falciparum K(1) (resistant to chloroquine and pyr