Immunopeptides in the defense reactions of <em>Glossina morsitans</em> to bacterial and <em>Trypanosoma brucei</em> <em>brucei</em> infections (Publications)
Several dipteran insects are vectors of parasites causing major human infectious diseases. Among these, the tsetse fly, Glossina spp., is responsible for the transmission of trypanosomes, the pathogen
Characterization of a defensin from the sand fly <em>Phlebotomus duboscqi</em> induced by challenge with bacteria or the protozoan parasite... (Publications)
Antimicrobial peptides are major components of the innate immune response of epithelial cells. In insect vectors, these peptides may play a role in the control of gut pathogens. We have analyzed antim
Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and... (Publications)
Taking advantage of the structural features of natural products showing anti-trypanosomatid activity, we designed and synthesized a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anth
Atropo-enantioselective total synthesis of knipholone and related antiplasmodial phenylanthraquinones (Publications)
The "lactone concept" has been efficiently employed for the first atropo-enantioselective synthesis of knipholone and related natural phenylanthraquinones. Besides the regio- and stereoselective const
Epithelial innate immunity. A novel antimicrobial peptide with antiparasitic activity in the blood-sucking insect<em> Stomoxys calcitrans</em> (Publications)
The gut epithelium is an essential interface in insects that transmit parasites. We investigated the role that local innate immunity might have on vector competence, taking Stomoxys calcitrans as a mo