Gestational SARS-CoV-2 infection in a Ugandan birth cohort: high incidence, mild maternal disease, and evidence of association with transient infant... (Publications)
Many questions remain about the prevalence and effects of SARS-CoV-2 infection in malaria-endemic African countries like Uganda, particularly in vulnerable groups such as pregnant women. We describe SARS-CoV-2 [...] immunoglobulin (Ig)G and IgM antibody responses and clinical outcomes in mother-infant dyads enrolled in malaria chemoprevention trials in Uganda. From December 2020-February 2022, among 400 unvaccinated pregnant
Multiplicity of <em>Plasmodium falciparum</em> infection following intermittent preventive treatment in infants (Publications)
Intermittent preventive treatment in infants with sulphadoxine-pyrimethamine (IPTi-SP) reduces malaria morbidity by 20% to 33%. Potentially, however, this intervention may compromise the acquisition of [...] of polyclonal infections (69.6% vs. 69.7%; P = 0.99). Adjusting for study site, current and prior malaria, parasite density, and season did not change this finding. CONCLUSIONS: IPTi-SP appears to have no
Elimination of <em>Schistosoma mansoni</em> in infected mice by slow release of artemisone (Publications)
anti-plasmodial activity, and reduced toxicity compared to other artemisinins in clinical use against malaria. We infected adult mice by subcutaneous injection of S. mansoni cercariae (about 200) and treated [...] release of the artemisone that was verified in vivo and in vitro bioassays using drug-sensitive malaria parasites. We found superior strong anti-schistosome effects up to a total reduction of worm number
<em>Plasmodium vivax</em> and <em>Plasmodium falciparum</em> infection dynamics: re-infections, recrudescences and relapses (Publications)
BACKGROUND: In malaria endemic populations, complex patterns of Plasmodium vivax and Plasmodium falciparum blood-stage infection dynamics may be observed. Genotyping samples from longitudinal cohort studies [...] CONCLUSION: The statistical model developed here provides a useful new tool for in-depth analysis of malaria data from longitudinal cohort studies, and future application to data sets with multi-locus genotyping
Activation of TCR Vδ1+ and Vδ1-Vδ2- γδ T cells upon controlled infection with <em>Plasmodium falciparum</em> in Tanzanian volunteers (Publications)
immune response to malaria remains incomplete. Clinical trials using whole-sporozoite-based vaccination approaches such as the Sanaria PfSPZ Vaccine, followed by controlled human malaria infection (CHMI)
First detection of N1575Y mutation in pyrethroid resistant <em>Anopheles gambiae</em> in Southern Côte d'Ivoire (Publications)
insecticide classes is widespread. In an agricultural area of Southern Cote d'Ivoire, the main malaria vector Anopheles coluzzii shows multiple resistance across insecticides mediated by both target site [...] mutation in Cote d'Ivoire, and as in other populations, it is found in both dominant West African malaria vector species. Continued monitoring of N1575Y is underway, as are studies to elucidate its contribution
Synthesis and evaluation of beta-carbolinium cations as new antimalarial agents based on pi-delocalized lipophilic cation (DLC) hypothesis (Publications)
efficacy. beta-Carbolinium compounds exhibit medium suppressive activity in vivo against rodent malaria
Antiprotozoal activities of epimeric aminobicycles (Publications)
sleeping sickness, and Plasmodium falciparum K-1, a multiresistant protozoan parasite which causes Malaria tropica. The results are compared to the activities of their formerly synthesized stereoisomers and
Synthesis and evaluation of beta-carbolinium cations as new antimalarial agents based on pi-delocalized lipophilic cation (DLC) hypothesis (Publications)
efficacy. beta-Carbolinium compounds exhibit medium suppressive activity in vivo against rodent malaria
Antiprotozoal activities of epimeric aminobicycles (Publications)
sleeping sickness, and Plasmodium falciparum K-1, a multiresistant protozoan parasite which causes Malaria tropica. The results are compared to the activities of their formerly synthesized stereoisomers and
