Synthesis and antiplasmodial activity of new N-[3-(4-{3-[(7-chloroquinolin-4-yl)amino]propyl}piperazin-1-yl)propyl]carboxamides (Publications)
-aminopropyl)piperazin-1-yl]propyl}-7-chloroquinolin-4-amine with polymer-bound carboxylic acids opened straightforward access to novel aminoquinolines with activity against Plasmodium falciparum strains
If I tweet will you cite later? Follow-up on the effect of social media exposure on article downloads and citations (Publications)
in terms of downloads (p = 0.72) and citations (p= 0.30) for all papers and when we stratified by open access status. CONCLUSIONS: Longer observation time did not increase the relative differences in the
Model-based integration of genomics and metabolomics reveals SNP functionality in <em>Mycobacterium tuberculosis</em> (Publications)
the antibiotic para-aminosalicylic acid. Our method is broadly applicable across microbial life, opening possibilities for the development of more selective treatment strategies.
Retention in care and virological failure among adult HIV+ patients on second-line ART in Rwanda: a national representative study (Publications)
METHODS: A two-stage cluster sampling design was undertaken. 49 of 340 health facilities linked to the open-source electronic medical record (EMR) system of Rwanda were randomly sampled. Data sampling criteria
A primaquine-chloroquine hybrid with dual activity against <em>Plasmodium</em> liver and blood stages (Publications)
Based on the optimized synthetic pathway, the compound is accessible in a smooth and versatile way and open for potential further molecular modification.
Targeting <em>Plasmodium</em> PI(4)K to eliminate malaria (Publications)
ylinositol-4-phosphate. Collectively, our data define PI(4)K as a key Plasmodium vulnerability, opening up new avenues of target-based discovery to identify drugs with an ideal activity profile for the
Malaria, climate variability, and interventions: modelling transmission dynamics (Publications)
population. The model captures some of the main mechanisms of human, parasite, and vector dynamics, and opens the possibility to forecast malaria in endemic regions, taking into account the interaction between
Assessing the Potential Health Impact of Omicron (Page)
https://www.swisstph.ch/en/news/assessing-the-potential-health-impact-of-omicron
Modelling unit has been setting up an open-access transmission model for COVID-19 since the beginning of the pandemic, building on its experience in malaria modelling. “Our OpenCOVID transmission model provides
Clinical Research | Research at Swiss TPH (Page)
https://www.swisstph.ch/en/about/med/clinical-research
viraemia in children and adolescents with HIV in Lesotho and Tanzania (GIVE MOVE trial): a multisite, open-label randomised controlled trial. Lancet Glob Health . 2024;12(8):e1312-e1322. DOI: 10.1016/s221 [...] factors for developing active tuberculosis among people living with HIV in Georgia 2019-2020 cohort. Open Forum Infect Dis . 2024;11(9):ofae466. DOI: 10.1093/ofid/ofae466 Related Topics Infectious Diseases
Swiss TPH Symposium: Global Health in the 21st Century (News)
https://www.swisstph.ch/en/news/news-detail/news/swiss-tph-symposium-global-health-in-the-21st-century
development and roll-out. Nicole Probst Hensch, Head of Epidemiology and Public Health at Swiss TPH opened the symposium with reflections on the role of science during the pandemic: ‘’Researchers often grow [...] as mirrors Samia Hurst-Majno from the University of Geneva and Swiss National COVID-19 Task Force opened Day 2 of the symposium: “Pandemics are mirrors – they show us our strengths and our weaknesses, our
