Imidazolopiperazines: lead optimization of the second-generation antimalarial agents (Publications)
mice. The optimized compounds were found to be more efficacious than the current antimalarials in a malaria mouse model. They exhibit moderate oral exposure in rat pharmacokinetic studies to achieve sufficient
Aligning new interventions with developing country health systems: target product profiles, presentation, and clinical trial design (Publications)
anticipated use of the intervention in target countries. Examples are provided from research on malaria vaccines that are also applicable to other new public health interventions
Using observed incidence to calibrate the transmission level of a mathematical model for <em>Plasmodium vivax</em> dynamics including case management... (Publications)
model is used to calculate local reproduction numbers in Panama and identify areas of sustained malaria transmission that should be targeted by control interventions.
Quantifying the impact of interventions against <em>Plasmodium vivax</em>: a model for country-specific use (Publications)
fictitious data, by simulating and comparing the impact of various intervention combinations on malaria risk and burden, this model could be a useful tool for strategic planning, implementation and resource
Estimation of the antirelapse efficacy of tafenoquine, using <em>Plasmodium vivax</em> genotyping (Publications)
Plasmodium vivax relapse prevention is a key treatment goal in malaria. Use of P. vivax genotyping in a multicenter, double-blind, randomized, placebo-controlled Phase IIb study in Peru, India, Thailand
Osama Seidahmed (People)
https://www.swisstph.ch/en/staff/profile/people/osama-seidahmed
c region. His work includes diverse operational outcomes in the battle against diseases such as malaria, dengue, Chikungunya, and Rift Valley fever. He also contributed to the teaching at a college level
Eric Huber (People)
https://www.swisstph.ch/en/staff/profile/people/eric-huber
monitoring of trials, mainly in resource-limited countries, focusing on neglected diseases such as malaria, tuberculosis and helminth infections. Through this work he has gained extensive experience in the
Activities (Page)
https://www.swisstph.ch/en/about/events/open-house-2023/activities
Swiss TPH: A Glimpse into the Past Clinical Research: Bringing a Drug to Market** Healthy Travel: Malaria, Rabies and Yellow Fever Stuffed Animal Hospital: Making Your Furry Friend Healthy Again* 1 st floor [...] Digital Health for Early Childhood Development Disease Detectives: Investigating an Outbreak** Malaria Maze: Navigating the Impenetrable Mosquito Net*/** From the Wild to Paper: Comic Creation with Fizzi**
Attributes of <em>Anopheles gambiae</em> swarms in South Central Uganda (Publications)
BACKGROUND: Anopheles gambiae continues to be widespread and an important malaria vector species complex in Uganda. New approaches to malaria vector control are being explored including population suppression
Identification of oleamide in <em>Guatteria</em> recurvisepala by LC/MS-Based <em>Plasmodium falciparum</em> thioredoxin reductase ligand binding... (Publications)
current research on applications of mass spectrometry to natural product drug discovery against malaria aims to screen plant extracts for new ligands to PLASMODIUM FALCIPARUM thioredoxin reductase ( PFTrxR) [...] regulation of the parasite and is validated as a promising target for therapeutic intervention against malaria. In the present study, detannified methanol extracts from GUATTERIA RECURVISEPALA, LICANIA KALLUNKIAE
