Searched for malaria.

1. Abnormal blood glucose concentrations on admission to a rural Kenyan district hospital: prevalence and outcome (Publications)

   Abnormal blood glucose concentrations on admission to a rural Kenyan district hospital: prevalence and outcome

   Relevance:

   a on admission was 7.3%. Severe illness, malnutrition, last meal > 12 hours ago, and a positive malaria slide were independently associated with hypoglycaemia. Overall, mortality in hypoglycaemic children

2. Flow cytometric analysis on cross-reactivity of human-specific CD monoclonal antibodies with splenocytes of <em>Aotus nancymaae</em>, a non-human... (Publications)

   Flow cytometric analysis on cross-reactivity of human-specific CD monoclonal antibodies with splenocytes of <em>Aotus nancymaae</em>, a non-human primate model for biomedical research

   Relevance:

   to explore complex host-pathogen interactions in non-human primate animal models, particularly in malaria vaccine research

3. In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models (Publications)

   In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models

   Relevance:

   (OZ277) is a promising antimalarial drug candidate that Ranbaxy Laboratories Limited and Medicines for Malaria Venture (MMV) are currently developing as a fixed combination with piperaquine. Here, we describe

4. Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities (Publications)

   Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities

   Relevance:

   plausible explanation for lack of significant activity of the inhibitors in the in vivo Pb mouse malaria model

5. Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary... (Publications)

   Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling

   Relevance:

   Despite recent progress in the fight against malaria, the emergence and spread of drug-resistant parasites remains a serious obstacle to the treatment of infections. We recently reported the development

6. Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the <em>Plasmodium falciparum</em> dUTPase (Publications)

   Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the <em>Plasmodium falciparum</em> dUTPase

   Relevance:

   Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) is a potential drug target for malaria. We previously reported some 5'-tritylated deoxyuridine analogues (both cyclic and acyclic) as selective

7. Flow cytometric analysis on cross-reactivity of human-specific CD monoclonal antibodies with splenocytes of <em>Aotus nancymaae</em>, a non-human... (Publications)

   Flow cytometric analysis on cross-reactivity of human-specific CD monoclonal antibodies with splenocytes of <em>Aotus nancymaae</em>, a non-human primate model for biomedical research

   Relevance:

   to explore complex host-pathogen interactions in non-human primate animal models, particularly in malaria vaccine research

8. Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the <em>Plasmodium falciparum</em> dUTPase (Publications)

   Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the <em>Plasmodium falciparum</em> dUTPase

   Relevance:

   Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) is a potential drug target for malaria. We previously reported some 5'-tritylated deoxyuridine analogues (both cyclic and acyclic) as selective

9. Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary... (Publications)

   Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling

   Relevance:

   Despite recent progress in the fight against malaria, the emergence and spread of drug-resistant parasites remains a serious obstacle to the treatment of infections. We recently reported the development

10. Structure-activity relationship studies of pyrrolone antimalarial agents (Publications)

    Structure-activity relationship studies of pyrrolone antimalarial agents

    Relevance:

    mammalian (L6) cells. Three representative compounds were selected for evaluation in a rodent model of malaria infection, and the best compound showed improved ability to decrease parasitaemia and a slight increase