A primaquine-chloroquine hybrid with dual activity against <em>Plasmodium</em> liver and blood stages (Publications)
We present a new class of hybrid molecules consisting of the established antiplasmodial drugs primaquine and chloroquine. No drug is known to date that acts comparably against all stages of Plasmodium
Characterization of choline uptake in<em> Trypanosoma brucei</em> procyclic and bloodstream forms (Publications)
Choline is an essential nutrient for eukaryotic cells, where it is used as precursor for the synthesis of choline-containing phospholipids, such as phosphatidylcholine (PC). According to published dat
Fit genotypes and escape variants of subgroup III <em>Neisseria meningitidis</em> during three pandemics of epidemic meningitis (Publications)
The genetic variability at six polymorphic loci was examined within a global collection of 502 isolates of subgroup III, serogroup A Neisseria meningitidis. Nine "genoclouds" were identified, consisti
The public health significance and control of schistosomiasis in China - then and now (Publications)
The description of schistosomiasis in China dates back more than two millennia. The disease caused social and economic hardship, and the rates of morbidity and mortality were high. In the mid 1950s, w
Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism (Publications)
Recognition of lipids by proteins is important for their targeting and activation in many signaling pathways, but the mechanisms that regulate such interactions are largely unknown. Here, we found tha
Vector-borne diseases in humans and animals: activities of the Swiss Tropical Institut and risks for Switzerland (Publications)
The recent outbreak of anaplasmosis in a Swiss cattle herd triggered a discussion of the risk of vector-borne diseases in animals and humans in relation to climate changes and other factors. This over
3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential (Publications)
A novel class of orally active antimalarial 3,5-diaryl-2-aminopyridines has been identified from phenotypic whole cell high-throughput screening of a commercially available SoftFocus kinase library. T
Geschlechtsunterschiede in Gesundheit und Gesundheitsverhalten (Publications)
The higher life expectancy of women is contrasting with the higher female morbidity known from health interview surveys and statistics on use of health services. In the Swiss Health Survey SOMIPOPS, w
