Early manifestations (pre-AIDS) of HIV-1 infection in Uganda (Publications)
OBJECTIVES: To describe the early manifestations of HIV-1 infection before the development of AIDS, in a rural Ugandan population. METHODS: Three monthly follow-up of HIV-1-infected and uninfected par
Reduced fertility associated with HIV: the contribution of pre-existing subfertility (Publications)
BACKGROUND: HIV-1 infection is associated with lower fertility among women in sub-Saharan Africa and this association is not explained by the frequency of sexual intercourse, illness, knowledge of HIV
Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual <em>Plasmodium falciparum</em> lysates: evidence for association with... (Publications)
There is longstanding evidence for a role of immunoglobulin (Ig)G in protection against malarial disease and infection. IgG1 and IgG3 have been shown to be particularly efficient at associating with m
Comparison of axillary, rectal and tympanic temperature measurements in children admitted with malaria (Publications)
We compared axillary, rectal and tympanic temperatures in children admitted with severe malaria. The axillary temperatures were 0.74 degrees C (95% limits of agreement -0.85 to 2.33 degrees C) less th
<em>Ex vivo</em> interferon-gamma immune response to thrombospondin-related adhesive protein in coastal Kenyans: longevity and risk of <em>Plasmodium... (Publications)
Thrombospondin-related adhesive protein (TRAP) of Plasmodium falciparum is currently being tested in human vaccine studies. However, its natural reactivity in the field remains poorly characterized. M
A randomised, controlled trial of once daily and multi-dose daily gentamicin in young Kenyan infants (Publications)
AIMS: To test the suitability of a simple once daily (OD) gentamicin regimen for use in young infants where routine therapeutic drug monitoring is not possible. METHODS: In an open, randomised, contro
Blood transfusion for severe anaemia in children in a Kenyan hospital [Research letter] (Publications)
Severe anaemia often secondary to malaria is a major contributor to child mortality in sub-Saharan Africa. We have confirmed that use of simple clinical and laboratory criteria can identify those chil
Genetic diversity of <em>Plasmodium falciparum</em> parasites from Kenya is not affected by antifolate drug selection (Publications)
The genotypes of merozoite surface protein-1, merozoite surface protein-2 and glutamine rich protein are frequently used to distinguish recrudescence from reinfection when parasitaemia reappears after
HIV-1 RNA levels in an African population-based cohort and their relation to CD4 lymphocyte counts and World Health Organization clinical staging (Publications)
Apart from a small number of reports from people who are based in hospitals, data on viral load in HIV-infected people in sub-Saharan Africa, where most infections occur, are lacking. We report serum