Pharmacokinetics of ivermectin metabolites and their activity against <em>Anopheles stephensi </em>mosquitoes (Publications)
treat worm infections and ectoparasites including lice and scabies mites. Furthermore, survival of malaria transmitting Anopheles mosquitoes is strongly decreased after feeding on humans recently treated [...] . Currently, mass drug administration of ivermectin is under investigation as a potential novel malaria vector control tool to reduce Plasmodium transmission by mosquitoes. A "post-ivermectin effect" has
Relationship between insecticide resistance profiles in <em>Anopheles gambiae</em> <em>sensu lato</em> and agricultural practices in Côte... (Publications)
BACKGROUND: Insecticide-based malaria vector control is increasingly undermined due to the development of insecticide resistance in mosquitoes. Insecticide resistance may partially be related to the use [...] s between the type of agricultural practices and certain insecticide resistance profiles in the malaria vector An. gambiae s.l. which might arise from the use of pesticides deployed for protecting crops
The <em>Plasmodium falciparum</em> histone methyltransferase PfSET10 is dispensable for the regulation of antigenic variation and gene expression in... (Publications)
The malaria parasite Plasmodium falciparum employs antigenic variation of the virulence factor P. falciparum erythrocyte membrane protein 1 (PfEMP1) to escape adaptive immune responses during blood infection [...] for life cycle progression in the mosquito vector or during liver stage development.IMPORTANCEThe malaria parasite Plasmodium falciparum infects hundreds of millions of people every year. To survive and
Gene Coverage Count and Classification (GC3): a locus sequence coverage assessment tool using short-read whole genome sequencing data, and its... (Publications)
BACKGROUND: The ability of malaria rapid diagnostic tests (RDTs) to effectively detect active infections is being compromised by the presence of malaria strains with genomic deletions at the hrp2 and hrp3
R. Geigy Award 2024: Cutting-Edge Research to Control Communicable and Non-Communicable Diseases in Côte D’Ivoire (News)
https://www.swisstph.ch/en/news/news-detail/news/r-geigy-award-2024-cutting-edge-research-to-control-communicable-and-non-communicable-diseases-in-cote-divoire
Department at Swiss TPH and Member of the Board at the R. Geigy-Foundation. New insecticides to control malaria and dengue fever The research work of Julien Zahouli, Emmanuelle Lisro, Laurence Yao and Marc Adou [...] insecticides to combat disease-transmitting mosquitoes such as Anopheles gambiae (vector of the malaria parasite) and Aedes aegypti (vector of the dengue virus). “Julien Zahouli, Emmanuelle Lisro, Laurence
New Understanding of Childhood Immune Systems May Improve Vaccine Efficacy (News)
https://www.swisstph.ch/en/news/news-detail/news/new-understanding-of-childhood-immune-systems-may-improve-vaccine-efficacy
months from infants and children living in Tanzania and Mozambique as part of the phase III RTS,S malaria vaccine trial. Groups of children that responded with better antibody titers to the RTS,S vaccine [...] Despite the success rates of childhood immunization, there are still many infectious diseases, such as malaria, that require vaccination-based interventions. It is likely that such solutions will come from a
“I Believe That Pharmaceutical Companies Can Do More than Providing Medicines” (Page)
https://www.swisstph.ch/en/impact-stories/i-believe-that-pharmaceutical-companies-can-do-more-than-providing-medicines
and bring medicines to market in low- and middle-income countries. We work on diseases such as malaria, leishmaniasis and dengue fever, which primarily affect poorer countries and marginalised communities [...] development of new medicines. We can’t tackle tomorrow’s challenges with the tools of yesterday. In malaria, where there hasn’t been a new medicine in 25 years, drug resistance is on the rise. Novartis, together [...] these communities. The success we have achieved as a global community...
Statistical and Mathematical Modelling | Swiss TPH (Page)
https://www.swisstph.ch/en/statistical-and-mathematical-modelling
disease patterns, and in mathematical and simulation modelling of infectious diseases, particularly malaria, tuberculosis and other poverty-related diseases. At Swiss TPH, we analyse a wide range of disease
Host cytoskeleton remodeling throughout the blood stages of <em>Plasmodium falciparum</em> (Publications)
asexual intraerythrocytic development of Plasmodium falciparum, causing the most severe form of human malaria, is marked by extensive host cell remodeling. Throughout the processes of invasion, intracellular
Predictors of residual antimalarial drugs in the blood in community surveys in Tanzania (Publications)
cross-sectional survey was conducted in 2015 in three regions of Tanzania with different levels of malaria endemicity. Interviews were conducted and blood samples collected through household surveys for further
