Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on... (Publications)
sub-micromolar range against Trypanosoma brucei rhodesiense and Trypanosoma cruzi, as well as the malaria parasite Plasmodium falciparum, which lack trypanothione metabolism. The inhibitors exhibit strong
Antiprotozoal activities of traditional medicinal plants from the Garhwal region of North West Himalaya, India (Publications)
Garhwal region of North West Himalaya for the treatment of protozoal infections and fever including malaria. MATERIALS AND METHODS: In vitro activity against erythrocytic stages of Plasmodium falciparum was
Synthesis, solution structure and immune recognition of an epidermal growth factor-like domain from <em>Plasmodium falciparum</em> merozoite surface... (Publications)
iented approach to the study and optimization of the antigenicity of the protein as a potential malaria vaccine candidate, whilst exploiting the immunopotentiating properties of influenza virosomes as
Antiplasmodial and antitrypanosomal activity of new esters and ethers of 4-dialkylaminobicyclo[2.2.2]octan-2-ols (Publications)
suffer from painful application, severe side effects and increasing resistance against these drugs. Malaria tropica kills more than 2 million people every year mainly due to growing drug resistance. 4-Dia
Solid phase synthesis and antiprotozoal evaluation of di- and trisubstituted 5'-carboxamidoadenosine analogues (Publications)
rapid increase of resistance to drugs commonly used in the treatment of tropical diseases such as malaria and African sleeping sickness calls for the prompt development of new safe and efficacious drugs
Antiprotozoal activities of some constituents of <em>Markhamia tomentosa</em> (Bignoniaceae) (Publications)
bloodstream trypomastigotes of Trypanosoma brucei rhodesiense (the species responsible for human malaria, visceral leishmaniasis and African trypanosomiasis, respectively). Although compounds 1 and 2 exhibited
Antigenic cross-reactivity between different alleles of the <em>Plasmodium falciparum </em>merozoite surface protein 2 (Publications)
encoding Plasmodium falciparum merozoite surface protein 2 (MSP2) was PCR amplified from blood of malaria patients, genotyped, and 19 distinct fragments were cloned and expressed in E. coli. The reactivity
Genesis of and trafficking to the Maurer's clefts of <em>Plasmodium falciparum</em>-infected erythrocytes (Publications)
Malaria parasites export proteins beyond their own plasma membrane to locations in the red blood cells in which they reside. Maurer's clefts are parasite-derived structures within the host cell cytoplasm
Living on the edge: a longitudinal study of <em>Anopheles funestus</em> in an isolated area of Mozambique (Publications)
BACKGROUND: Understanding the survival strategies of malaria vectors at the edges of their distribution, where they are under stress from environmental conditions, may lead to the development of novel
Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in <em>Plasmodium falciparum</em> (Publications)
family, undergoes antigenic variation and plays an important role in chronic infection and severe malaria. Only a single var gene is transcribed per parasite, and epigenetic control mechanisms are fundamental
