An efficient system to generate monoclonal antibodies against membrane-associated proteins by immunisation with antigen-expressing mammalian cells (Publications)
present study, we applied this approach successfully for three predicted GPI-anchored proteins of the malaria parasite Plasmodium falciparum. CONCLUSIONS: The described entirely cell-based technology is a fast
MAHRP2, an exported protein of <em>Plasmodium falciparum</em>, is an essential component of Maurer's cleft tethers (Publications)
Summary Upon invasion into erythrocytes, the malaria parasite Plasmodium falciparum must refurbish the host cell. The objective of this study was to elucidate the location and function of MAHRP2 in these
<em>Plasmodium falciparum</em> centromeres display a unique epigenetic makeup and cluster prior to and during schizogony (Publications)
organisms. The centromeres of Plasmodium falciparum, the causative agent of the most severe form of malaria have been broadly mapped on most chromosomes, but their epigenetic composition remained undefined
Selection and reversal of <em>Plasmodium berghei</em> resistance in the mouse model following repeated high doses of artemether (Publications)
Artemether, a derivative of artemisinin, is effectively used for the treatment of malaria without any clinically relevant resistance to date. Artemether has also been developed as an antischistosomal agent
Identification of a cis-acting DNA-protein interaction implicated in singular var gene choice in <em>Plasmodium falciparum</em> (Publications)
Plasmodium falciparum is responsible for the most severe form of malaria in humans. Antigenic variation of P. falciparum erythrocyte membrane protein 1 leads to immune evasion and occurs through switches
<em>In vitro</em> assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of <em>Plasmodium falciparum</em> (Publications)
OBJECTIVES: Using synchronous cultures of Plasmodium falciparum malaria, the stage sensitivity of the parasite to OZ277 (RBx-11160), the first fully synthetic antimalarial peroxide that has entered Phase
Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals (Publications)
such as the semisynthetic artemisinins are critically important in the treatment of drug-resistant malaria. Nevertheless, their peroxide bond-dependent mode of action is still not well understood. Using
Genetic analysis of IgG subclass responses against RESA and MSP2 of <em>Plasmodium falciparum</em> in adults in Papua New Guinea (Publications)
complex than governed by a single major gene. Such host genetic variation in responses to specific malaria antigens has implications for immuno-epidemiology and vaccine development
Screening medicinal plants for the detection of novel antimalarial products applying the inhibition of beta-hematin formation (Publications)
identification of novel scaffolds for the development of effective and safe treatments to fight malaria is urgently needed. One of the main opportunities is the discovery of new molecules from natural
Blood schizontocidal and gametocytocidal activity of 3-hydroxy-N'-arylidenepropanehydrazonamides: a new class of antiplasmodial compounds (Publications)
moiety, demonstrated in vivo antiplasmodial activity after oral administration in a P. berghei malaria model, although no complete parasite elimination was achieved with a four-dose regimen. The in vivo
