Passive immunoprotection of <em>Plasmodium falciparum</em>-infected mice designates the CyRPA as candidate malaria vaccine antigen (Publications)
malaria. In an endeavor to identify novel vaccine targets, we tested predicted Plasmodium falciparum open reading frames for proteins that elicit parasite-inhibitory Abs. This has led to the identification
Reinvestigation of the <em>Saccharomyces cerevisiae</em> genome annotation by comparison to the genome of a related fungus: <em>Ashbya gossypii</em> (Publications)
syntenic regions leading to an improved annotation. RESULTS: We have identified 23 novel S. cerevisiae open reading frames (ORFs) as syntenic homologs of A. gossypii genes; for all but one, homologs are present
Connecting the Dots. Teaching, Research and Services in the Great Lakes Region (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/connecting-the-dots-teaching-research-and-services-in-the-great-lakes-region
Research and Services in the Great Lakes Region” was to complement the portfolio of the Swiss TPH office opened in Bukavu with a strong capacity building component in implementation research of young researchers
Tuberculosis mortality and living conditions in Bern, Switzerland, 1856-1950 (Publications)
in 1856 to 33 per 100,000 in 1950, as housing conditions improved, indoor crowding decreased, and open-air schools, sanatoria, systematic tuberculin skin testing of school children and chest radiography
Integrating standardized whole genome sequence analysis with a global <em>Mycobacterium tuberculosis</em> antibiotic resistance knowledgebase (Publications)
from MTBC sequence data. Stringent thresholds and quality control measures were incorporated in this open source tool. The pipeline was validated using a well-characterized dataset of 90 diverse MTBC isolates
Short course amphotericin B in addition to sertraline and fluconazole for treatment of HIV-associated cryptococcal meningitis in rural Tanzania (Publications)
activity against Cryptococcus and bi-directional synergy with fluconazole. METHODS: We conducted an open label clinical trial to assess the safety and efficacy of sertraline 400 mg/day and fluconazole 1200
Collaborating with Complementary and Alternative Medicine (CAM) providers when writing HPV vaccine review articles (Publications)
important to VH HCPs. Contrary to our initial expectations, and in an inclusive, respectful atmosphere of open dialogue, we were able to productively finalize our manuscripts. In the opinion of the CAM co-authors
wIRA: hyperthermia as a treatment option for intracellular bacteria, with special focus on Chlamydiae and Mycobacteria (Publications)
infections are presented. Finally, technical aspects of using wIRA in patients are critically reviewed and open questions driving future research are highlighted. In conclusion, wIRA is a promising tool for reducing
Modeling indoor air pollution of outdoor origin in homes of SAPALDIA subjects in Switzerland (Publications)
indoors were between 30% and 66%, the highest one was observed for PMabsorbance. A modifying effect of open windows was found for NO2 and the ultrafine particle number concentration. Cooking was associated
Functional characterization and phenotypic monitoring of human hematopoietic stem cell expansion and differentiation of monocytes and macrophages by... (Publications)
e blood monocytes-derived from HSC-derived macrophages. To conclude, we propose that this method opens new avenues to distinguish the impact of human genetics on the dysregulated biological properties
