Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species (Publications)
rheumatoid arthritis indicates that it could be safe and efficacious for treating malaria. We sought to establish a murine malaria model to study the mechanism of action and resistance of MTX and its analogue [...] receptor/transport to gain access to cells, their lack of efficacy against the four tested murine malaria species may be the result of inefficiency of drug transport
Synthetic GPI array to study antitoxic malaria response (Publications)
Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI [...] on a synthetic GPI glycan array to correlate anti-GPI antibody levels and protection from severe malaria
Residual antimalarial concentrations before treatment in patients with malaria from Cambodia: indication of drug pressure (Publications)
at reducing inappropriate drug use. Methods. Baseline samples from 125 patients with falciparum malaria recruited for 2 in vivo studies (in Preah Vihear and Pursat provinces) were analyzed for the presence [...] (25% and 35% of patients) and piperaquine (15% of patients); the first-line drug against vivax malaria, chloroquine (25% and 41% of patients); and the former first-line drug, quinine (5% and 34% patients)
Towards a comprehensive simulation model of malaria epidemiology and control (Publications)
SUMMARYPlanning of the control of Plasmodium falciparum malaria leads to a need for models of malaria epidemiology that provide realistic quantitative prediction of likely epidemiological outcomes of a [...] dynamics, limit the applicability of conventional deterministic malaria models. We use individual-based stochastic simulations of malaria epidemiology to predict the impacts of interventions on infection