Analysis of nucleic acids extracted from rapid diagnostic tests reveals a significant proportion of false positive test results associated with recent... (Publications)
Surveillance programmes often use malaria rapid diagnostic tests (RDTs) to determine the proportion of the population carrying parasites in their peripheral blood to assess the malaria transmission intensity. Despite [...] quality control activities for RDTs deployed in malaria surveillance programmes. Methods: The diagnostic performance of field-deployed RDTs used for malaria surveys was assessed by retrospective molecular [...] P. falciparum histidine rich protein 2 (PfHRP2) antigen...
Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case-control study (Publications)
ted BTM correlations with malaria risk appeared to generalize to healthy, malaria-naive adults. CONCLUSIONS: A prevaccination transcriptomic signature associates with malaria in RTS,S/AS01-vaccinated African [...] we assessed the generalizability of our findings across three controlled human malaria infection studies of healthy, malaria-naive adult RTS,S/AS01 recipients. RESULTS: RTS,S/AS01 vaccination was associated [...] month 3 levels correlated with malaria risk. In contrast, baseline levels...
Infectivity of symptomatic malaria patients to <em>Anopheles farauti</em> colony mosquitoes in Papua New Guinea (Publications)
to mosquitoes is an understudied bottleneck in the transmission of malaria. Direct membrane feeding assays (DMFA) allow detailed malaria transmission studies from humans to mosquitoes. Especially for Plasmodium [...] were performed with venous blood collected from rapid diagnostic test (RDT) positive symptomatic malaria patients and subsequently analysed by light microscopy and quantitative real time polymerase chain
Haematological consequences of acute uncomplicated <em>falciparum </em>malaria: a WorldWide Antimalarial Resistance Network pooled analysis of... (Publications)
falciparum malaria to identify the factors associated with malarial anaemia. METHODS: Individual patient data from eligible antimalarial efficacy studies of uncomplicated P. falciparum malaria, available [...] BACKGROUND: Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of [...] = 2.06 [95%CI 1.39-3.05], p < 0.001). CONCLUSIONS: In patients with uncomplicated...
Revisiting the effect of pharmaceuticals on transmission stage formation in the malaria parasite <em>Plasmodium falciparum</em> (Publications)
Malaria parasites rely on specialized stages, called gametocytes, to ensure human-to-human transmission. The formation of these sexual precursor cells is initiated by commitment of blood stage parasites [...] vivo. These observations suggest that therapeutic interventions may promote gametocytogenesis and malaria transmission. Here, we engineered a P. falciparum reporter line to quantify sexual commitment rates [...] rates after exposure to antimalarials and other pharmaceuticals commonly...
Multi-insecticide resistant malaria vectors in the field remain susceptible to malathion, despite the presence of <em>Ace1</em> point mutations (Publications)
Insecticide resistance in Anopheles mosquitoes is seriously threatening the success of insecticide-based malaria vector control. Surveillance of insecticide resistance in mosquito populations and identifying the
Der lange Weg zur ersten Impfung gegen Malaria (Publications)
langen Weg: Die Weltgesundheitsorganisation hat jüngst den Einsatz des ersten Impfstoffes gegen Malaria zum breitflächigen Einsatz bei Kindern in den betroffenen Ländern empfohlen. Dennoch braucht es