Group | Helminths and Health

Schistosomiasis on Zanzibar

On the Zanzibar islands (Unguja and Pemba) belonging to the United Republic of Tanzania in East Africa, our research focuses on transdisciplinary intervention approaches that can contribute to the interruption of urogenital schistosomiasis transmission on Zanzibar. In addition preventive chemotherapy, we explore the impact of snail control and novel behavior change approaches. We also collaborate with other international institutions on the development and evaluation of new diagnostic tests for urogenital schistosomiasis. Read more about the project

Liver Fluke in Siberia

In rural Siberia, Russian Federation, the liver fluke (Opisthorchis felineus) has been neglected for several decades. We contribute to the clarification of the epidemiology and infection and morbidity burden in Siberia, Russian Federation.

Helminth infections are a group of neglected tropical diseases with a high impact on human health. The aim of this research group is to understand the diversity of parasitic helminths, their epidemiology and their impact on health at individual and population levels and to design and evaluate adequate control strategies. The group has developed a special interest and expertise in helminthiases of Southeast Asian, East-Africa and Siberia (Russian Federation).

Helminth Infections in Southeast Asia

Southeast Asia with Laos and Cambodia is of particular interest due to its unique socio-cultural and eco-epidemiological environment in the Mekong sub-region. Mekong schistosomiasis (Schistosoma mekongi), liver fluke (Opisthorchis viverrini), threadworm (Strongyloides stercoralis) and co-infections with soil-transmitted helminths are highly prevalent and lead frequently to polyparasitism and to liver and intestinal morbidity. With a collaborative research approach we assess the contribution of helminth infections to overall infection and morbidity burden.

Buonfrate D, Hunt V.L, Odermatt P, Streit A. Strongyloides: omics to worm-free populations. Philos Trans R Soc Lond B Biol Sci. 2024;379(1894):20220448. DOI: 10.1098/rstb.2022.0448

Homsana A et al. Steatotic liver disease among lean and non-lean individuals in Southern Lao PDR: a cross-sectional study of risk factors. Ann Med. 2024;56(1):2329133. DOI: 10.1080/07853890.2024.2329133

Kamber L, Bürli C, Harbrecht H, Odermatt P, Sayasone S, Chitnis N. Modeling the persistence of Opisthorchis viverrini worm burden after mass-drug administration and education campaigns with systematic adherence. PLoS Negl Trop Dis. 2024;18(2):e0011362. DOI: 10.1371/journal.pntd.0011362

O'Connor S.Y et al. Examining the acceptability of helminth education packages "Magic Glasses Lower Mekong" and "Magic Glasses Opisthorchiasis" and their impact on knowledge, attitudes, and practices among schoolchildren in the Lower Mekong Basin: protocol for a cluster rand. JMIR Res Protoc. 2024;13:e55290. DOI: 10.2196/55290

Sayasone S, Vonghachack Y, Xia S, Lv S, Zhou X.N, Odermatt P. Integrated Eco-Health approach significantly reduces helminth infections in endemic Khong islands with emphasis on Schistosoma mekongi. Infect Dis Poverty. 2024;13(1):57. DOI: 10.1186/s40249-024-01226-z